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    Phytochemical Analysis, Antipropulsive and Antilymphoma Activities of Leaves Extract of Annona cherimola Miller

    Fernando Calzada1★, Miguel Valdés1, Verenice Itzel Merlin1, Claudia Velázquez2, Elizabeth Barbosa3, Marco Chávez‑Soto1, Emmanuel Pina‑Jiménez4, Rosa Maria Ordoñez‑Razo4, Normand García‑Hernández4★ Corresponding author

    1. 1Unidad de Investigación Médica en Farmacología, Unidad Médica de Alta Especialidad, Hospital de Especialidades‑2° Piso CORSE Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Cd México, 1Área Académica de Farmacia, Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, San Agustin Tlaxiaca, Pachuca, Hidalgo, Mexico.
    2. 2Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luís y Díaz Mirón, Mexico.
    3. 3Unidad de Investigación Médica en Genética Humana Unidad Médica de Alta Especialidad, Hospital de Pediatría. Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Cd Mexico.

    CORRESPONDENCE

    Fernando Calzada

    Unidad de Investigación Médica en Farmacología, Unidad Médica de Alta Especialidad, Hospital de Especialidades‑2° Piso CORSE Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Cd México, 1Área Académica de Farmacia, Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, San Agustin Tlaxiaca, Pachuca, Hidalgo, Mexico.

    fercalber10@gmail.com

    Received: 18-10-2019; Revised: 06-12-2019; Accepted: 16-12-2019.

    Volume 16, Issue 69 · pp. 317–320 · PUBLISHED 15 June 2020 · DOI: 10.4103/pm.pm_462_19

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Objectives: The present work reports the identification of flavonol glycosides present in the ethanol crude extract using high‑performance liquid chromatography with diode array detection (HPLC‑DAD). Materials and Methods: The identification of flavonoids was made by comparing their retention times and ultraviolet spectra with those standards. The crude extract, dichloromethane, and aqueous residual (AR) fractions were tested for their antipropulsive and antilymphoma activities. Results: The results revealed high levels of three flavonoid glycosides (rutin, nicotiflorin, and narcissin), especially rutin (24.5 mg/g of extract). The antipropulsive and antilymphoma activities of the leaf extract and subsequent fractions showed that the ethanol extract of the leaves of A. cherimola is cursive and AR fraction exhibited the best biological effects in both assays. Conclusion: The HPLC‑DAD method used in this work enables the determination of rutin as a major flavonol glycoside of the leaves of A. cherimola. In addition, it can be suggested that rutin may play an important role in the biological properties of A. cherimola.

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      Calzada, F., Valdés, M., Merlin, V. I., Velázquez, C., Barbosa, E., Chávez‑Soto, M., Pina‑Jiménez, E., Ordoñez‑Razo, R. M., & García‑Hernández, N. (2020). Phytochemical Analysis, Antipropulsive and Antilymphoma Activities of Leaves Extract of Annona cherimola Miller. Pharmacognosy Magazine, 16(69), 317–320. https://doi.org/10.4103/pm.pm_462_19