Phcog.Net logo
Submit

BROWSE ALL JOURNALS

    SEE ALL 6 JOURNALS
    Pharmacognosy MagazineNOW IN
    Article

    Anti-inflammatory and Analgesic Activities of Cissus quadrangularis L. Methanolic Extract in Experimental Animal Models

    Eunson Hwang1, Sul Woong Park1, Jung‑Eun Yang1★★ Corresponding author

    1. 1Seoul Hightech Venture Center, SD Biotechnologies Co., Ltd., Ganseo‑Gu, Seoul, Korea.

    CORRESPONDENCE

    Jung‑Eun Yang

    Seoul Hightech Venture Center, SD Biotechnologies Co., Ltd., Ganseo‑Gu, Seoul, Korea.

    jungeun_y@sdbiotech.co.kr

    Received: 09-09-2019; Revised: 13-11-2019; Accepted: 26-12-2019.

    Volume 16, Issue 69 · pp. 336–340 · PUBLISHED 15 June 2020 · DOI: 10.4103/pm.pm_326_19

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Aim: In this study, the skin-protective effects of two geographical types of EBN (EBN‑A and EBN‑B) were investigated. Materials and Methods: The anti-aging effect was assessed in ultraviolet B (UVB)‑irradiated normal human dermal fibroblasts (NHDFs), while the anti‑inflammatory effect was evaluated in tumor necrosis factor alpha/interferon gamma (TNF‑α/IFN‑γ)‑stimulated human skin keratinocytes (HaCaTs). The wound‑healing activity was investigated in scratched NHDFs and hyalorunan production was examined in HaCaTs. Results: In this study, EBN showed good efficiency in scavenging free radicals. EBN notably decreased the UVB‑induced matrix metalloproteinase‑1 expression and promoted procollagen type I synthesis that resulted in the protective effect of EBN against UVB‑induced skin damage. Overexpression of thymus‑ and activation‑regulated chemokine and macrophage‑derived chemokine induced by TNF‑α/IFN‑γ was significantly decreased after treatment with EBN at 1–10 μg/ml. The most effective wound healer was EBN‑B at 1–10 μg/ml, based on the high expression of hyaluronan that has long been associated with the remodeling extracellular matrix in wound healing. Conclusion: These results indicate that EBNs have the potential to ameliorate UVB‑induced skin photo aging and NF‑α/ IFN‑γ‑stimulated inflammation as well as wound injuries, resulting in rapid healing effects.

    KEYWORDS

    Open in new tab

    REFERENCES

    As published

    Showing references and in-text citations exactly as published.

      Cite this article

      SELECT FORMAT

      Hwang, E., Park, S. W., & Yang, J. (2020). Anti-inflammatory and Analgesic Activities of Cissus quadrangularis L. Methanolic Extract in Experimental Animal Models. Pharmacognosy Magazine, 16(69), 336–340. https://doi.org/10.4103/pm.pm_326_19