Effects of the Japanese Kampo Medicine, Rikkunshito, on Gastrointestinal Motility Functions
Minwoo Hwang1, Donghun Han2, Byung Joo Kim2★★ Corresponding author
- 1Department of Sasang Constitutional Medicine, College of Korean Medicine, Kyung Hee University, Seoul.
- 2Division of Longevity and Biofunctional Medicine, School of Korean Medicine, Pusan National University, Yangsan, Korea.
CORRESPONDENCE
Byung Joo Kim
Division of Longevity and Biofunctional Medicine, School of Korean Medicine, Pusan National University, Yangsan, Korea.
Received: 18-09-2019; Revised: 20-11-2019; Accepted: 26-12-2019.
Volume 16, Issue 69 · pp. 343–346 · PUBLISHED 15 June 2020 · DOI: 10.4103/pm.pm_370_19
View on Pharmacogn. Mag. original site ↗
ABSTRACT
Objectives: The objective was to find the effect of GI motility with Rikkunshito. Materials and Methods: The prokinetic effect of Rikkunshito was investigated by studying the gastric emptying (GE) and intestinal transit rate (ITR) or experimentally induced GI motility dysfunction (GMD). Results: The oral administration of Rikkunshito significantly increased GE and ITR and restored the delayed GE and ITR. Its effect was similar to that of conventional prokinetics, such as domperidone and mosapride. Moreover, we made the mouse GMD models, such as acetic acid or streptozotocin, and ITR had shown a great decrease. This decrease was recovered by Rikkunshito. Conclusion: Rikkunshito revealed its prokinetic effect through an increase of GE and ITR. We found a great possibility of Rikkunshito for the GI control drug.
KEYWORDS
REFERENCES
As publishedShowing references and in-text citations exactly as published.
Cite this article
SELECT FORMAT
Hwang, M., Han, D., & Kim, B. J. (2020). Effects of the Japanese Kampo Medicine, Rikkunshito, on Gastrointestinal Motility Functions. Pharmacognosy Magazine, 16(69), 343–346. https://doi.org/10.4103/pm.pm_370_19