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    Article

    Synthesis, Characterization, and Biological Activity of Silver Nanoparticles Synthesized from Aristolochia bracteolata Lam.

    Nagaraja Sreeharsha2,3★, Govindarajan Kathiravan4, Kalyanaraman Rajagopal4, Arvindganth Rajasekar5, Bose Rajangam6, Bandar E. Aldhubiab2, Venugopala Narayanaswamy2,7, Mahesh Attimarad2, Anroop B. Nair2, Rajith Kumar Karnathi8, Girish Meravanige9, Uma Chandur10, Teeka S. Roopashree11, Micheline Haroun2, Christophe Tratrat2★ Corresponding author

    1. 1Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al‑Ahsa, Saudi Arabia.
    2. 2Department of Pharmaceutics, Vidya Siri College of Pharmacy, Bengaluru, Karnataka.
    3. 3Department of Botany, Ramakrishna Mission Vivekananda College, Chennai.
    4. 4Department of Biochemistry, Elayampalayam, Tiruchangode, Erode, College of Clinical Pharmacy, King Faisal University, Al‑Ahsa, Saudi Arabia.
    5. 5Deparment of Biotechnology, Vel’s University, Chennai, Tamil Nadu, India.
    6. 6Department of Biotechnology and Food Technology, Durban University of Technology, Durban, South Africa.
    7. 7Department of Chemistry, College of Science, King Faisal University.
    8. 8Department of Biomedical Sciences, College of Medicine, King Faisal University, Al‑Ahsa, Saudi Arabia.
    9. 9Department of Pharmacognosy, Vidya Siri College of Pharmacy.
    10. 10Department of Pharmacognosy, Government College of Pharmacy, Bengaluru, Karnataka, India.

    CORRESPONDENCE

    Nagaraja Sreeharsha

    Department of Pharmaceutics, Vidya Siri College of Pharmacy, Bengaluru, Karnataka.

    sharsha@kfu.edu.sa

    Received: 14-06-2020; Revised: 01-07-2020; Accepted: 24-07-2020.

    Volume 16, Issue 71 · pp. 568–573 · PUBLISHED 20 October 2020 · DOI: 10.4103/pm.pm_313_20

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    The aim of this research is to analyze the antimicrobial activity and cytotoxicity of biologically synthesized silver nanoparticles against A549 cancer cell line. Silver nanoparticles were synthesized from the leaf extract of Aristolochia bracteolata. For the characterization of silver nanoparticles, Fourier transform infrared, high‑performance liquid chromatography, and ultraviolet techniques were adopted. The silver nanoparticle was found to show better antimicrobial activity when compared to the crude extract of the plant. Noteworthy cytotoxic effects against A549 cell line were shown by the nanoparticles derived from the plant extract. Following the potential of biologically synthesized silver nanoparticles, they can be a valuable addition to the treatment of human laryngeal carcinoma and can be categorized as a potent anticancer agent.

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      Sreeharsha, N., Kathiravan, G., Rajagopal, K., Rajasekar, A., Rajangam, B., Aldhubiab, B. E., Narayanaswamy, V., Attimarad, M., Nair, A. B., Karnathi, R. K., Meravanige, G., Chandur, U., Roopashree, T. S., Haroun, M., & Tratrat, C. (2020). Synthesis, Characterization, and Biological Activity of Silver Nanoparticles Synthesized from Aristolochia bracteolata Lam.. Pharmacognosy Magazine, 16(71), 568–573. https://doi.org/10.4103/pm.pm_313_20