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    Article

    Fracture Healing in SD Rats’ Bioactivities of Cucumber Seed Polysaccharides

    Zhihong Zhang2, Yuanning Zeng3, Donghui Peng2, Na Xing4, Haodong Bai2, Yuxin Li2, Na Cui2, Huilin Su3, Tingting Qiao3, Congjing Shi3, Haixue Kuang2★, Qiuhong Wang2,3★★ Corresponding author

    1. 1Department of Chinese Medicine Processing, Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin, China.
    2. 2Department of Chinese Medicine Processing, School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, China.
    3. 3Zhongshan Institude for Drug Discovery, Zhongke Zhongshan Institute of Drug Innovation, Zhongshan, China.

    CORRESPONDENCE

    Haixue Kuang

    Department of Chinese Medicine Processing, School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, China.

    hxkuang@hljucm.net

    Received: 12-01-2022; Revised: 21-05-2022; Accepted: 19-07-2022.

    Volume 18, Issue 79 · pp. 738–745 · PUBLISHED 19 September 2022 · DOI: 10.4103/pm.pm_14_22

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: We investigated the composition and structure of intracellular polysaccharides in cucumber seeds (CSs) and their effect on Sprague-Dawley (SD) rats and potential activity for fracture healing. Materials and Methods: Polysaccharides are its main water‑soluble active ingredient. The SD rat tibia fracture model was established by surgical method, and the healing effect of cucumber seed polysaccharides (CSPs) on SD rat tibia fracture was preliminarily explored. Through histopathological observation, determination of rat serum indicators alkaline phosphatase (AKP), acid phosphatase (ACP), BGP, X‑ray imaging observation, and micro‑Computed Tomography (CT) imaging observation at different periods. Results and Conclusion: The results showed that CSP enhanced the activity of osteoblasts, increased the metabolic rate of osteoclasts, increased the secretion of AKP, BGP, and ACP, shortened the fracture healing time of SD rats and effectively promoted the healing of tibial fractures in SD rats.

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      Zhang, Z., Zeng, Y., Peng, D., Xing, N., Bai, H., Li, Y., Cui, N., Su, H., Qiao, T., Shi, C., Kuang, H., & Wang, Q. (2022). Fracture Healing in SD Rats’ Bioactivities of Cucumber Seed Polysaccharides. Pharmacognosy Magazine, 18(79), 738–745. https://doi.org/10.4103/pm.pm_14_22