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    Ameliorative Potential of Betanin on Cigarette Smoke Extract-induced Respiratory Mucosal Inflammation and Oxidative Stress in the Adult Zebrafish Model

    Ibrahim Alqasmi1★★ Corresponding author

    1. 1Department of Public Health, School of Health Sciences, Saudi Electronic University, Faisaliyah, SAUDI ARABIA.

    CORRESPONDENCE

    Ibrahim Alqasmi

    Department of Public Health, School of Health Sciences, Building B, Saudi Electronic University, Jeddah City Sary Road, Faisaliyah, SAUDI ARABIA.

    i.alqasmi@seu.edu.sa

    Volume 19, Issue 2 · pp. 244–253 · PUBLISHED 2023 · DOI: 10.1177/09731296221145075

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Betanin, a natural pigment and glycosidic bioactive compound, possesses anti-inflammatory antioxidant activity. Objectives: In this study, we evaluated the potential effect of betanin on cigarette smoke extract (CSE)-induced pulmonary inflammation in the zebrafish model. Materials and Methods: Zebrafish were randomly divided into five groups with control, CSE-exposed and betanintreated after CSE exposure for 3 and 6 days. Oxidative stress-related parameters like reactive oxygen species (ROS), nitric oxide (NO) and myeloperoxidase (MPO) were analysed, histopathological studies were carried out and gene expression of proinflammatory tumour necrosis factor-alpha, inducible NO synthase and anti-inflammatory interleukin-10 cytokines was determined. Results: Treatment with betanin reduced ROS, MPO and NO with histopathological improvement, alleviating CSE-induced pulmonary inflammation. Further, decreased expression of the proinflammatory gene and increased expression of the antiinflammatory gene were observed after 6 days of treatment. Conclusion: Betanin exhibits a protective effect against CSE exposure by inhibiting oxidative stress and inflammation.

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      Alqasmi, I. (2023). Ameliorative Potential of Betanin on Cigarette Smoke Extract-induced Respiratory Mucosal Inflammation and Oxidative Stress in the Adult Zebrafish Model. Pharmacognosy Magazine, 19(2), 244–253. https://doi.org/10.1177/09731296221145075