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    Article

    Influence of Drying Condition on Nutritional and Chemical Profile of Garcinia pedunculata Roxb. Fruit

    Swarnali Bhattacharjee1,2, Elancheran Ramakrishnan3, Prashanta Kumar Deb1,4, Partha Pratim Sarma1, Debopriya Choudhury1, Senthamaraikannan Kabilan3, Rajlakshmi Devi1★★ Corresponding author

    1. 1Life Science Division, Institute of Advanced Study in Science and Technology (IASST), Guwahati, Assam, INDIA.
    2. 2Department of Zoology, Gauhati University, Guwahati, Assam, INDIA.
    3. 3Drug Discovery Lab, Department of Chemistry, Annamalai University, Annamalai Nagar, Tamil Nadu, INDIA.
    4. 4Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Shoolini University, Solan, Himachal Pradesh, INDIA.

    CORRESPONDENCE

    Rajlakshmi Devi

    Life Science Division, Institute of Advanced Study in Science and Technology (IASST), Guwahati, Assam 781035, INDIA.

    rajlakshmi@iasst.gov.in

    Received: 20-05-2022; Accepted: 20-09-2022.

    Volume 19, Issue 2 · pp. 269–283 · PUBLISHED 2023 · DOI: 10.1177/09731296231158433

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Garcinia pedunculata (GP) Roxb. is a traditional medicinal plant used for treating gastrointestinal disorders. The fruit is always consumed in dried form in cuisines and as medicine. Objectives: To study the effect of drying conditions (shade, oven, and traditional sun drying) on the nutritional profile of GP while assessing the choice of solvent extraction for the maximum phytocompounds extraction; their in vitro biological activities and chemical profiling. Materials and Methods: The fruits were cut into thin 0.9 ± 0.3 cm slices and dried in the shade (25–30°C), sun (34–40°C), and oven (70–80°C). The extraction was done using methanol, hydromethanol, ethanol, hydroethanol, and water. HPLC and LC-ESI-MS/MS were used to identify the bioactive compounds. Results: In this study, the impact of three drying conditions has been investigated and established that shade-dried (ShD) has a better-preserved nutritional profile. In terms of phytochemical extraction, comparatively higher amounts of phenols (394.00 ± 12.28 mg Gallic acid equivalent (GAE)/g of dried sample) and flavonoids (72.62 ± 2.06 mg Quercetin/g of dried sample) were recorded in the shade-dried hydromethanolic extract (ShDMH), which was directly in line with the better antioxidant activity (IC50 for 1,1-diphenyl-2-picrylhydrazyl (DPPH), 647.99 ± 7.66 µg/mL, 2,2′-azino-bis(3-ethylbenzothiazoline)6-sulfonic acid (ABTS), 762.02 ± 18.74 µg/mL) and enzyme-inhibitory potential (IC50 for α- glucosidase 1908.06 ± 13.26 µg/mL and for lipase 613.59 ± 7.57 µg/mL) of this extract. Conclusion: The conclusive evidence from this study indicates that shade drying and extraction with hydromethanolic solvent preserves most of the nutritional components and has a higher extraction yield with well-conserved phytochemical composition. Also, these bioactive compounds such as hydroxycitric acid, GB-1a, garcinone A, 9-hydroxycalabaxanthone, chlorogenic acid, and garcinol are present in these extracts. This fruit, although beneficial is still underutilized, and this outcome is believed to be significantly valuable for the further aspects of GP fruit-based nutraceutical or phytopharmaceutical development.

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      Bhattacharjee, S., Ramakrishnan, E., Deb, P. K., Sarma, P. P., Choudhury, D., Kabilan, S., & Devi, R. (2023). Influence of Drying Condition on Nutritional and Chemical Profile of Garcinia pedunculata Roxb. Fruit. Pharmacognosy Magazine, 19(2), 269–283. https://doi.org/10.1177/09731296231158433