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    Article

    Research on the Improvement of Endothelial Cell Function and Trophoblast Apoptosis in Rats with Preeclampsia by Tanshinone IIA

    Hui Dong1, Jie Song1,4, Yanju Jia2, Hongyan Cui2, Xu Chen1★★ Corresponding author

    1. 1School of Medicine, Nankai University, Tianjin, CHINA.
    2. 2Department of Obstetrics, Tianjin Central Hospital of Gynecology Obstetrics, Tianjin, CHINA.
    3. 3Tianjin Key Laboratory of Human Development and Reproductive Regulation, Tianjin, CHINA.
    4. 4Department of Gynecology, Tianjin Central Hospital of Gynecology Obstetrics, Tianjin, CHINA.
    5. 5Tianjin Medical University, Tianjin, China.

    CORRESPONDENCE

    Xu Chen

    School of Medicine, Nankai University, Tianjin, CHINA.

    chenxudoo2665@163.com

    Received: 28-05-2024; Accepted: 31-07-2024.

    Volume 21, Issue 1 · pp. 116–123 · PUBLISHED 2025 · DOI: 10.1177/09731296241277301

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Preeclampsia is a pregnancy complication characterized by high blood pressure and signs of damage to another organ system, often the kidneys. Recent studies suggest that endothelial dysfunction and trophoblast apoptosis are involved in the pathogenesis of preeclampsia. Objectives: To investigate the effects of tanshinone IIA (TIIA) on clinical symptoms, vascular endothelial function, and placental trophoblast apoptosis in preeclampsia rats. Materials and Methods: Twenty-four pregnant Sprague-Dawley rats, between 8 and 10 weeks old, were randomly divided and allocated into three groups: Control, model, and treatment, with each group consisting of 8 rats. The control group received normal saline injections via the tail vein; the model group received NG-nitro-l-arginine methyl ester (l-NAME) to induce preeclampsia, followed by normal saline injections; and the treatment group received TIIA (10 mg/kg) via tail vein injection after preeclampsia induction with l-NAME. Various parameters were measured, including tail artery systolic pressure, 24-hour proteinuria, offspring and placental weight, levels of endothelial nitric oxide synthase (eNOS), endothelin-1 (ET-1), placental growth factor (PLGF), and soluble FMS-like tyrosine kinase 1 (sFlt-1) in serum, and expression of B-cell lymphoma-2 (Bcl-2) and Bcl-2-related X protein (Bax) in placental trophoblasts. Results: TIIA treatment led to decreased tail artery systolic pressure and 24-hour urine protein levels, increased body and placental weights of offspring, and favorable changes in serum levels of ET-1, sFlt-1, eNOS, and PLGF. Moreover, TIIA treatment resulted in decreased Bax levels and apoptosis in placental trophoblasts, along with increased Bcl-2 levels. Conclusion: TIIA can improve the clinical symptoms of preeclampsia in rats induced by l-NAME, alleviate the apoptosis of placental trophoblast cells, and improve vascular endothelial function.

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      Dong, H., Song, J., Jia, Y., Cui, H., & Chen, X. (2025). Research on the Improvement of Endothelial Cell Function and Trophoblast Apoptosis in Rats with Preeclampsia by Tanshinone IIA. Pharmacognosy Magazine, 21(1), 116–123. https://doi.org/10.1177/09731296241277301