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    Study on Action and Mechanism of Potentilla discolor Bunge using Patch-Clamp to Explore the Effect of the Main Components of Potentilla discolor Bunge on Myocardial Cell Membranes

    Yanxin Dang1, Wenjie Zhao2, Xiaohan Li2, Yongchao Chen2, Jie Liu1, Lin Li2, Minzhen Xie3, Zhouxiu Chen2, Siqi Gu3, Qi Wang3★, Guijun Liu1★ Corresponding author

    1. 1Department of Dermatology, the Fourth Clinical Medical College of Heilongjiang University of Traditional Chinese Medicine, Harbin, Heilongjiang, CHINA.
    2. 2Department of Pharmacology (The State-Province Key Laboratories of Biomedicine Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang, CHINA.
    3. 3Department of Medicinal Chemistry and Natural Medicinal Chemistry, College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang, CHINA.

    CORRESPONDENCE

    Qi Wang

    Department of Medicinal Chemistry and Natural Medicinal Chemistry, College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang, CHINA.

    wangqiby1987@hotmail.com

    Received: 12-12-2023; Accepted: 31-07-2024.

    Volume 21, Issue 1 · pp. 124–132 · PUBLISHED 2025 · DOI: 10.1177/09731296241280347

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Potentilla discolor Bunge (PDB) is a plant of the Rosaceae family. A wide range of pharmacological activities, such as antibacterial, hypoglycemic, and others, can be achieved through its chemical components, which include terpenes, steroids, polyphenols, and flavonoids. However, the effects of the herb on the heart are unclear. Objectives: To explore the effect of the main components of PDB on myocardial cell membranes. Materials and Methods: We investigated the role of different concentrations of PDB in cardiomyocytes by evaluating myocardial electrical activity. We used high-performance liquid chromatography to analyze the components. Patch-clamp experiments were conducted to detect the drugs’ impact on the ion channels of cardiomyocytes. Results: PDB regulated 14 potential metabolites in mice. Interestingly, quercetin exerts certain effects on the heart by acting on the inositol phosphate metabolism pathway. Quercetin is a monomer compound that can enhance the activity of IK1 on the myocardium membrane. Conclusion: This study showed that monomeric compounds of PDB can significantly enhance IK1 activity and influence ion channels in a concentration-dependent manner.

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      Dang, Y., Zhao, W., Li, X., Chen, Y., Liu, J., Li, L., Xie, M., Chen, Z., Gu, S., Wang, Q., & Liu, G. (2025). Study on Action and Mechanism of Potentilla discolor Bunge using Patch-Clamp to Explore the Effect of the Main Components of Potentilla discolor Bunge on Myocardial Cell Membranes. Pharmacognosy Magazine, 21(1), 124–132. https://doi.org/10.1177/09731296241280347