Phcog.Net logo
Submit

BROWSE ALL JOURNALS

    SEE ALL 6 JOURNALS
    Pharmacognosy MagazineNOW IN
    Article

    Antihyperglycemic and antihyperlipidemic effects of guar gum on streptozotocin-induced diabetes in male rats

    Samarghandian Saeed2★, Hadjzadeh Mosa-Al-Reza2,3, Amin Nya Fatemeh4, Davoodi Saeideh2★ Corresponding author

    1. 1Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
    2. 2Neuroscience Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
    3. 3Department of Biology, Mashhad Azad University, Mashhad, Iran.

    CORRESPONDENCE

    Samarghandian Saeed

    Neuroscience Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

    Received: 22-10-2010; Revised: 08-12-2010.

    Volume 8, Issue 29 · pp. 65–72 · PUBLISHED 28 February 2012 · DOI: 10.4103/0973-1296.93328

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Herbal medicine is widely used in the treatment of diseases like diabetes mellitus. We investigated the effects of guar gum in diabetic rats for the reduction of the risk of diabetes and cardiovascular disease. Dietary pattern emphasizing foods high in complex carbohydrates and fi ber are associated with low blood glucose and cholesterol levels. Materials and Methods: Diet containing 0%, 5%, 10% and 20% (w/w) guar gum was fed to diabetic rats for 28 days. Blood serum glucose, triglycerides, cholesterol, low-density lipoprotein cholesterol (LDL-C), high- density lipoprotein cholesterol levels, atherogenic index levels, body weights and food intake were monitored at 0, 7.14 and 28 days after induction of diabetes. Results: In spite of the fact that diabetes elevated blood lipids in all rats after 14 days, the guar gum diet signifi cantly decreased the serum concentration of cholesterol, triacylglicerols and LDL-C and atherogenic index. The most signifi cant result in this study was the reduction of blood glucose in diabetic rats treated with the guar gum diet after 28 days versus non- and glibenclamide-treated rats. The gum promoted a general improvement in the condition of the diabetic rats in body weight and food intake in comparison with nontreated rats. Conclusion: The results of this research suggest that guar gum was signifi cantly effective in comparison with glibenclamide in the treatment of hyperlipidemia and hyperglycemia in diabetes rats. Therefore, it may be suggested as a reliable fi ber in diabetic regimes in diabetic patients.

    KEYWORDS

    Open in new tab

    REFERENCES

    As published

    Showing references and in-text citations exactly as published.

      Cite this article

      SELECT FORMAT

      Saeed, S., Mosa-Al-Reza, H., Fatemeh, A. N., & Saeideh, D. (2012). Antihyperglycemic and antihyperlipidemic effects of guar gum on streptozotocin-induced diabetes in male rats. Pharmacognosy Magazine, 8(29), 65–72. https://doi.org/10.4103/0973-1296.93328