Volume 11, Issue 42s

Original Article

1. Article

   S1 Cytotoxic glucosphingolipid from Celtis Africana

   Shagufta Perveen, Areej Mohammad Al‑Taweel, Ghada Ahmed Fawzy, Azza Muhammed El‑Shafae, Afsar Khan, Peter Proksch

   pp. 1–5 · DOI: 10.4103/0973-1296.157662 · Published 27 May 2015

   Background: Literature survey proved the use of the powdered sun‑dried bark and roots of Celtis africana for the treatment of cancer in South Africa. Objective: The aim of this study was to do further isolation work on t…

2. Article

   Cytotoxicity of some edible mushrooms extracts over liver hepatocellular carcinoma cells in conjunction with their antioxidant and antibacterial properties

   Gökhan Sadi, Buğrahan Emsen, Abdullah Kaya, Aytaç Kocabaş, Seval Çınar, Deniz İrtem Kartal

   pp. 6–18 · DOI: 10.4103/0973-1296.157665 · Published 27 May 2015

   Background: Mushrooms have been valued for their nutritive content and as traditional medicines; several important medicinal properties of mushrooms have been recognized worldwide. Objective: The purpose of this study wa…

3. Article

   S19 Pharmacophore modeling, in silico screening, molecular docking and molecular dynamics approaches for potential alpha‑delta bungarotoxin‑4 inhibitors discovery

   R. Barani Kumar, M. Xavier Suresh, B. Shanmuga Priya

   pp. 19–28 · DOI: 10.4103/0973-1296.157670 · Published 27 May 2015

   Background: The alpha‑delta bungartoxin‑4 (α‑δ‑Bgt‑4) is a potent neurotoxin produced by highly venomous snake species, Bungarus caeruleus, mainly targeting neuronal acetylcholine receptors (nAchRs) and producing adverse…

4. Article

   S29 Antimutagenic potential of harpagoside and Harpagophytum procumbens against 1‑nitropyrene

   Luigi Manon, Baghdikian Béatrice, Orsière Thierry, Pompili Jocelyne, Mabrouki Fathi, Ollivier Evelyne

   pp. 29–36 · DOI: 10.4103/0973-1296.157675 · Published 27 May 2015

   Background: 1‑nitropyrene (1‑NPy) is one of the most abundant nitro‑polycyclic aromatic hydrocarbons particularly in diesel exhausts. It is a mutagenic and carcinogenic pollutant very widespread in the environment. So th…

5. Article

   S37 Cytotoxic and apoptotic effects of Ebenus boissieri Barbey on human lung cancer cell line A549

   Esra Arslan Aydemir, Ece Simsek, Nilüfer Imir, Ramazan Süleyman Göktürk, Erdem Yesilada

   pp. 37–45 · DOI: 10.4103/0973-1296.157679 · Published 27 May 2015

   Background: Fabaceae family members are known to possess preventive and therapeutic potentials against various types of cancers. Objective: The aim of this study was to investigate the cytotoxic and apoptotic effects of …

6. Article

   Antiproliferative efficacy of Tabernaemontana divaricata against HEP2 cell line and Vero cell line

   Arvind Kumar, S. Selvakumar

   pp. 46–52 · DOI: 10.4103/0973-1296.157682 · Published 27 May 2015

   Background: Laryngeal cancer may also be called cancer of the larynx or laryngeal carcinoma. Conventional plants are a precious source of novel anticancer agents and are still in performance better role in health concern…

7. Article

   Assay method for quality control and stability studies of a new anti‑diabetic and anti‑dyslipidemic flavone (S002‑853)*

   Arshi Naqvi, Anuja Pandey, Varsha Gupta, Richa Malasoni, Akansha Srivastava, Rishi Ranjan Pandey, M. Satyanarayana, Ram Pratap, Anil Kumar Dwivedi

   pp. 53–59 · DOI: 10.4103/0973-1296.157689 · Published 27 May 2015

   Background: Flavonoid‑rich extract of the plant is long known for its anti‑diabetic activities in traditional medicine. S002‑853, a new flavone derivative synthesized by Central Drug Research Institute (CDRI) has been us…

8. Article

   Use of bergenin as an analytical marker for standardization of the polyherbal formulation containing Saxifraga ligulata

   Hulikal Basavarajaiah Pushpalatha, Kumar Pramod, Rajendran Devanathan, Ramachandran Sundaram

   pp. 60–65 · DOI: 10.4103/0973-1296.157690 · Published 27 May 2015

   Background: Bergenin is the principle constituent of the well-known medicinal plant Saxifraga ligulata. Bergenin has anti-inflammatory, antipyretic, antiviral, immunostimulant, antihyperglycemic, and antioxidant properti…

9. Article

   A novel high‑performance liquid chromatography‑electron spray ionization‑mass spectrometry method for simultaneous determination of guggulsterones, piperine and gallic acid in Triphala guggulu

   Ganesh Muguli, P. R. Rao Vadaparthi, B. Ramesh, Vishakante Gowda, Rangesh Paramesh, Atul N. Jadhav, K. Suresh Babu

   pp. 66–72 · DOI: 10.4103/0973-1296.157696 · Published 27 May 2015

10. Article

    S73 Anti‑lung cancer potential of pure esteric‑glycoside condurangogenin A against nonsmall‑cell lung

    cancer cells in vitro via p21/p53 mediated cell cycle

    pp. 73–85 · DOI: 10.4103/0973-1296.157698 · Published 27 May 2015

    Background: Marsdenia condurango (condurango) is a tropical woody vine native to South America. Our earlier study was limited to evaluation of anti‑cancer potentials of crude condurango extract and its glycoside‑rich com…

11. Article

    Protective effect of young green barley leaf (Hordeum vulgare L.) on restraint stress‑induced decrease in hippocampal brain‑derived neurotrophic factor in mice

    Katsunori Yamaura, Riho Tanaka, Yuanyuan Bi, Hideki Fukata, Nobuo Oishi, Hiromi Sato, Chisato Mori, Koichi Ueno

    pp. 86–92 · DOI: 10.4103/0973-1296.157702 · Published 27 May 2015

    Background: Many health experts support the hypothesis that stressful lifestyles are the leading cause of illness, like depression. Therefore, from the standpoint of preventive medicine, it is important to reduce stress.…

12. Article

    S93 Toxicological and biochemical studies on Schinus terebinthifolius concerning its curative and hepatoprotective effects against carbon tetrachloride‑induced liver injury

    Rania H. Abdou, Sherif Y. Saleh, Waleed F. Khalil

    pp. 93–101 · DOI: 10.4103/0973-1296.157705 · Published 27 May 2015

    Background: Recently, many efforts have been made to discover new products of natural origin which can limit the xenobiotic‑induced hepatic injury. Carbon tetrachloride (CCl4) is a highly toxic chemical that is widely us…

13. Article

    Flavonoid profile, antioxidant and cytotoxic activity of different extracts from Algerian Rhamnus alaternus L. bark

    Soulef Boussahel, Antonio Speciale, Saliha Dahamna, Yacine Amar, Irene Bonaccorsi, Francesco Cacciola, Francesco Cimino, Paola Donato, Guido Ferlazzo, Daoud Harzallah, Mariateresa Cristani

    pp. 102–109 · DOI: 10.4103/0973-1296.157707 · Published 27 May 2015

    Background: Rhamnus alaternus (Rhamnaceae) L. has been traditionally used for treatment of many diseases. Objective: In this study, we determined the antioxidant/free radical scavenger properties, the flavonoid profile a…

14. Article

    Inhibitory potential of some Romanian medicinal plants against enzymes linked to neurodegenerative diseases and their antioxidant activity

    Gabriela Paun, Elena Neagu, Camelia Albu, Gabriel Lucian Radu

    pp. 110–116 · DOI: 10.4103/0973-1296.157709 · Published 27 May 2015

    Context: Eryngium planum, Geum urbanum and Cnicus benedictus plants are an endemic botanical from the Romanian used in folk medicine. Objective: The extracts from three Romanian medicinal plants were investigated for the…

15. Article

    Experimental treatment of breast cancer‑bearing BALB/c mice by artemisinin and transferrin‑loaded magnetic nanoliposomes

    Amir Gharib, Zohreh Faezizadeh, Seyed Ali Reza Mesbah‑Namin, Ramin Saravani

    pp. 117–122 · DOI: 10.4103/0973-1296.157710 · Published 27 May 2015

    Background: The combination of artemisinin and transferrin exhibits versatile anticancer activities. In previous, we successfully prepared artemisinin and transferrin‑loaded magnetic nanoliposomes and evaluated their ant…

16. Article

    In silico analysis and molecular docking studies of potential angiotensin‑converting enzyme inhibitor using quercetin glycosides

    Syed Aun Muhammad, Nighat Fatima

    pp. 123–126 · DOI: 10.4103/0973-1296.157712 · Published 27 May 2015

17. Article

    Methanol extract of wheatgrass induces G1 cell cycle arrest in a p53‑dependent manner and down regulates the expression of cyclin D1 in human laryngeal cancer cells‑an in vitro and in silico approach

    Garima Shakya, Sangeetha Balasubramanian, Rukkumani Rajagopalan

    pp. 139–147 · DOI: 10.4103/0973-1296.157715 · Published 27 May 2015

    Background: Deregulation of cell cycle has been implicated in the malignancy of cancer. Since many years investigation on the traditional herbs has been the focus to develop novel and effective drug for cancer remedies. …

18. Article

    The dose dependent in vitro responses of MCF- 7 and MDA-MB-231 cell lines to extracts of Vatica diospyroides symington type SS fruit include effects on mode of cell death

    Theera Srisawat, Yaowapa Sukpondma, Potchanapond Graidist, Siriphon Chimplee, Kanyanatt Kanokwiroon

    pp. 148–155 · DOI: 10.4103/0973-1296.157718 · Published 27 May 2015

    Background: Vatica diospyroides type LS is a known source of valuable compounds for cancer treatment, however, in contrast little is known about therapeutic efficacy of type SS. Objective: This study focused on in vitro …

19. Article

    Cytotoxic activity of Macrosolen parasiticus (L.) Danser on the growth of breast cancer cell line (MCF‑7)

    Vijay Kumar Sodde, Richard Lobo, Nimmy Kumar, Rajalekshmi Maheshwari, C. S. Shreedhara

    pp. 156–160 · DOI: 10.4103/0973-1296.157719 · Published 27 May 2015

    Background: Macrosolen parasiticus (L.) Danser belonging to Loranthaceaea (mistletoe family) is a parasitic plant that grows on different host plants such as mango, jack fruit, peepal, neem tree, etc., This study was aim…

20. Article

    Effects of the extract and glycoalkaloids of Solanum lycocarpum St. Hill on Giardia lamblia trophozoites

    Gilmarcio Z. Martins, Raquel R. D. Moreira, Cleopatra S. Planeta, Adélia E. Almeida, Jairo K. Bastos, Lígia Salgueiro, Carlos Cavaleiro, Maria do Céu Sousa

    pp. 161–165 · DOI: 10.4103/0973-1296.157721 · Published 27 May 2015

    Background: Solanum lycocarpum has great importance for food and medicinal traditional use. Recently, it was also evidenced that extracts of S. lycocarpum St. Hill (Solanaceae) and its glycoalkaloids, solamargine (Sg) an…

21. Article

    Development of response surface methodology for optimization of extraction parameters and quantitative estimation of embelin from Embelia ribes Burm by high performance liquid chromatography

    Md. Shamsir Alam, Zoheir A. Damanhouri, Aftab Ahmad, Lubna Abidin, Mohd Amir, Mohd Aqil, Shah Alam Khan, Mohd Mujeeb

    pp. 166–172 · DOI: 10.4103/0973-1296.157722 · Published 27 May 2015

    Background: Embelia ribes Burm is widely used medicinal plant for the treatment of different types of disorders in the Indian traditional systems of medicine. Objective: The present work was aimed to optimize the extract…

22. Article

    Hepatorenal protective effect of Antistax® against chemically‑induced toxicity

    Atallah F. Ahmed, Hanan M. Al‑Yousef, Jawaher H. Al‑Qahtani, Mansour S. Al‑Said, AbdelKader E. Ashour, Mohammed Al‑Sohaibani, Syed Rafatullah

    pp. 173–181 · DOI: 10.4103/0973-1296.157726 · Published 27 May 2015

    Background: Antioxidant natural products and chemoprevention are considered nowadays as an effective approach against health various disorders and diseases induced by oxidative stress or free radicals. Objective: The aim…

23. Article

    Neuroprotective effects of Nigella sativa extracts during germination on central nervous system

    Mohammad Hayatul Islam, Iffat Zareen Ahmad, Mohammad Tariq Salman

    pp. 182–189 · DOI: 10.4103/0973-1296.157729 · Published 27 May 2015

    Background: Nigella sativa Linn. which has many acclaimed medicinal properties is an indigenous herbaceous plant and belongs to the Ranunculaceae family, which grows in countries bordering the Mediterranean Sea, Pakistan…

24. Article

    The potential of selected Australian medicinal plants with anti‑Proteus activity for the treatment and prevention of rheumatoid arthritis

    I. E. Cock, V. Winnett, J. Sirdaarta, B. Matthews

    pp. 190–208 · DOI: 10.4103/0973-1296.157734 · Published 27 May 2015

    Background: A wide variety of herbal medicines are used in indigenous Australian traditional medicinal systems to treat rheumatoid arthritis (RA) and inflammation. The current study was undertaken to test the ability of …

25. Article

    Protective role of Kalpaamruthaa in type II diabetes mellitus‑induced cardiovascular disease through the modulation of protease‑activated receptor‑1

    Raja Latha, Palanivelu Shanthi, Panchanadham Sachdanandam

    pp. 209–216 · DOI: 10.4103/0973-1296.157739 · Published 27 May 2015

    Background: Kalpaamruthaa (KA) is a formulatory herbal preparation has beneficial antioxidant, anti‑apoptotic and anti‑inflammatory properties against cardiovascular damage (CVD). Objective: The present study was underta…

26. Article

    Pharmacological and phytochemical evaluation of Ocimum sanctum root extracts for its antiinflammatory, analgesic and antipyretic activities

    Anant Kumar, Karishma Agarwal, Anil Kumar Maurya, Karuna Shanker, Umme Bushra, Sudeep Tandon, Dnyaneshwar U. Bawankule

    pp. 217–224 · DOI: 10.4103/0973-1296.157743 · Published 27 May 2015

    Background: Long‑term use of nonsteroidal anti‑inflammatory drugs (NSAIDs) increases risk of having a range of gastrointestinal problems. Therefore, new anti‑inflammatory, analgesic, antipyretic drugs having lesser side …

27. Article

    Phytoecdysteroids of the East Asian Caryophyllaceae

    Elena Novozhilova, Viacheslav Rybin, Petr Gorovoy, Irina Gavrilenko, Roman Doudkin

    pp. 225–230 · DOI: 10.4103/0973-1296.157746 · Published 27 May 2015

    Background: Occurrence of integristerone A (1), 20‑hydroxyecdysone (2), ecdysone (3), 2‑deoxy‑20‑hydroxyecdysone (4) has been analyzed in 64 species of the East Asian Caryophyllaceae. Materials and Methods: Ecdysteroid c…

1. Article

   Development and extraction optimization of baicalein and pinostrobin from Scutellaria violacea through response surface methodology

   Shankar Subramaniam, Ravikumar Raju, Anbumathi Palanisamy, Aravind Sivasubramanian

   pp. 127–138 · DOI: 10.4103/0973-1296.157714 · Published 27 May 2015

   Objective: To develop a process that involves optimization of the amount of baicalein and pinostrobin from the hydro‑methanolic extract of the leaves of Scutellaria violacea by response surface methodology (RSM). Materia…