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    Article

    Antifouling Alkaloids from Crinum augustum (Amaryllidaceae)

    John Refaat1, Ahmed Abdel-Lateff1★, Mohamed S. Kamel1, Ahmed A. Ali2, Mahmoud A. Ramadan2, Tatsufumi Okino3, Yasuyuki Nogata4★ Corresponding author

    1. 1aPharmacognosy Department, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt.
    2. 2bPharmacognosy Department, Faculty of Pharmacy, Assiut University, Egypt.
    3. 3cFaculty of environmental earth science, Hokkaido University, Sapporo, 060-0810, Japan
    4. 4dCentral Research Institute of Electric Power Industry, Biology Department, 1646 Abiko, Chiba 270-1194 Japan

    CORRESPONDENCE

    Ahmed Abdel-Lateff

    *Telephone & Fax 002-086-2369075

    aabelazim@yahoo.co.uk

    Received: 02-01-2009; Accepted: 22-06-2009.

    Volume 1, Issue 2 · pp. 43–52 · PUBLISHED Mar-Apr 2009 · DOI:

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Fractionation and purification of the ethanolic extract of the bulbs of Crinum augustum Rox. (Amaryllidaceae) cultivated in Egypt yielded five alkaloids 6-methoxy-crinamine (1), crinamine (2), buphanisine (3), ungeremine (4), and hippadine (5); two fatty acid derivatives: myristic acid ethyl ester (6) and palmitic acid ethyl ester (7); four terpenoidal and steroidal compounds: ursolic acid (8), β-sitosterol-O- β glucopyranoside (9) and mixture of β- sitosterol (10) and stigmasterol (11). The structures of all compounds were determined by interpretation of their spectroscopic data; 1D (1H and 13C), 2D (HSQC, COSY, DQF, NOE and HMBC) NMR; MS and UV analyses. The compounds (1-4) and (6-8) were tested towards biofouling activity using larvae of barnacle Balance amphitrie. Significant activities of 1, 2 and 3 with EC50 1.8, 1.2 and 0.75 µg/mL respectively, were observed.

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      Refaat, J., Abdel-Lateff, A., Kamel, M. S., Ali, A. A., Ramadan, M. A., Okino, T., & Nogata, Y. (2009). Antifouling Alkaloids from Crinum augustum (Amaryllidaceae). Pharmacognosy Research, 1(2), 43–52.