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    Article

    Dermal Wound Healing Effect of Pistacia Lentiscus Fruit’s Fatty Oil.

    N. Boulebda1, A. Belkhiri1,2★, F. Belfadel3, A. Bensegueni4, L. Bahri3★ Corresponding author

    1. 1aLaboratoire de Phytopharmacognosie et Pharmacochimie des Substances Naturelles. Urmedco, Faculté de Médecine, UM Constantine. Algérie - 25000
    2. 2bLaboratoire de Pharmaco-Toxicologie, UM Constantine. Algérie - 25000
    3. 3cDépartement de Biologie, Faculté des Sciences biologiques, UM Constantine, Algérie - 25000
    4. 4dDépartement des sciences vétérinaires, faculté des Sciences biologiques, UM Constantine, Algérie – 25000

    CORRESPONDENCE

    A. Belkhiri

    *For correspondence :

    belkhiri_abdelmalik@yahoo.fr

    Received: 28-01-2009; Accepted: 16-02-2009.

    Volume 1, Issue 2 · pp. 66–71 · PUBLISHED Mar-Apr 2009 · DOI:

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Several natural products have been shown to accelerate wound healing process. The present study was undertaken to evaluate the effect of Pistacia lentiscus fruits fatty oil on cutaneous wound healing in rat, and to compare this effect to that of saponifiable and unsaponifiable oily fractions. Full-thickness excision wounds were made on the back of anesthetised rats. The fruit’s oil and the two fractions were assessed together with a conventional drug, i.e. Madecassol®. Preparations were topically applied on the area of excised wounded once a day and assessed for a period of 26 days. During this period, wound area was measured and photographically documented. Wound contraction, expressed as percentage, was significantly (P<0.05) enhanced in the presence of Pistacia lentiscus oil, unsaponifiable oily fraction and Madecassol® treatments compared to the control, untreated animals. Furthermore, wound healing potentially effect was more pronounced in case of the oily unsaponifiable fraction- treated group compared to the others groups. Results clearly substantiate the healing potential effect on wound of a topic application of the Pistacia lentiscus fruits fatty oil and its unsaponifiable fraction.

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      Boulebda, N., Belkhiri, A., Belfadel, F., Bensegueni, A., & Bahri, L. (2009). Dermal Wound Healing Effect of Pistacia Lentiscus Fruit’s Fatty Oil.. Pharmacognosy Research, 1(2), 66–71.