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    Cytotoxic acetogenins from Annona glabra cultivated in Egypt

    Ahmed Abdel-lateff1★, Bassem S. El-Menshawi2, Mohamed Y. Haggag3, Mahmoud A. Nawwar4★ Corresponding author

    1. 1aPharmacognosy Department, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt.
    2. 2bPharmacognosy Department, National Research Centre Dokki, 12622 Giza, Egypt.
    3. 3cPharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
    4. 4dTanning and Protein Department, National Research Centre Dokki, Giza Egypt

    CORRESPONDENCE

    Ahmed Abdel-lateff

    *Telephone & fax 002-086-2369075

    aabelazim@yahoo.co.uk

    Received: 10-03-2009; Accepted: 09-04-2009.

    Volume 1, Issue 3 · pp. 130–135 · PUBLISHED May-Jun 2009 · DOI:

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Bio-assay guided fraction of the methanolic extract of Annona glabra seeds (Annonaceae), cultivated in Egypt, revealed to the isolation of three bis-tetrahydrofuran acetogenins; squamocin-C (1), squamocin-D (2), and annonin I (3). Compounds 1 and 2 were obtained as stereoisomeric mixture. All isolates were assayed for their cytotoxicity twards brine shrimp and five in vitro cancer cell lines (A549, HT29, MCF 7, RPMI, and U251), and showed significant activity The structures of all compounds were determined by interpretation of their NMR and MS analyses.

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      Abdel-lateff, A., El-Menshawi, B. S., Haggag, M. Y., & Nawwar, M. A. (2009). Cytotoxic acetogenins from Annona glabra cultivated in Egypt. Pharmacognosy Research, 1(3), 130–135.