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    Central Nervous System Activity of Phenol‑Rich Fraction of Piper sylvaticum Roots

    Akash Ved1★, Amresh Gupta1, Om Prakash1, Ajay Kumar Singh Rawat2★ Corresponding author

    1. 1Department of Pharmacy, Goel Institute of Pharmacy and Sciences, INDIA.
    2. 2Department of Pharmacognosy and Ethnopharmacology, CSIR‑National Botanical Research Institute, Lucknow, Uttar Pradesh, INDIA.

    CORRESPONDENCE

    Akash Ved

    Department of Pharmacy, Goel Institute of Pharmacy and Sciences, INDIA.

    akashved@gmail.com

    Volume 10, Issue 4 · pp. 339–342 · PUBLISHED · DOI: 10.4103/pr.pr_125_17

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Obective:Piper sylvaticumRoxb. is an important folk medicine in Indian Traditional System of Medicine widely used by different tribes in many countries. In the present study, the anticonvulsant activity of extract/fractions of Piper sylvaticum (PS) roots was investigated. Materials and Methods: 70% ethanolic extract of PS roots was successively extracted using hexane and ethyl acetate to prepare various fractions. Total phenol content was found at maximum 324.65 mg/gallic acid equivalent/g in ethyl acetate fraction (EAF) (phenol‑rich fraction [PRF]). High‑performance thin‑layer chromatography fingerprinting profiling of PS roots was performed. The anticonvulsant properties of the EAF of roots of PS were examined by maximal electroshock method as compared to standard phenytoin (25 mg/kg body weight). Result: It was found that EAF shows potent anticonvulsant activity at different dose levels against maximum electroshock seizure‑induced convulsions in Swiss albino mice. Conclusion:From the observation, it can be concluded that the current study has expressed that the phenol‑rich EAF of the ethanolic extract of the roots of PS has shown the dose‑dependent anticonvulsant effect in mice. The anticonvulsant potential may be due to the presence of phenolic compounds in PRF. The outcomes suggested a high potential for application of EAF of PS root as an anticonvulsant agent.

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      Ved, A., Gupta, A., Prakash, O., & Rawat, A. K. S. (). Central Nervous System Activity of Phenol‑Rich Fraction of Piper sylvaticum Roots. Pharmacognosy Research, 10(4), 339–342. https://doi.org/10.4103/pr.pr_125_17