Volume 10, Issue 4

Original Article

1. Article

   Antithrombotic Activity and Saponin Composition of the Roots of Panax bipinnatifidus Seem. Growing in Vietnam

   Vu Thi Thom, Nguyen Huu Tung, Dang Van Diep, Dang Thi Thuy, Nguyen Thi Hue, Dinh Doan Long, Bui Thanh Tung, Pham Thanh Huyen, Duong Thi Ly Huong

   pp. 333–338 · DOI: 10.4103/pr.pr_58_18 · Published

   Background: Panax bipinnatifidus(PB) Seem. is a highly valuable and indigenous medicinal plant wildly distributed in the northwest region of Vietnam. The PB root has been used as a tonic in Vietnamese traditional medicin…

2. Article

   Central Nervous System Activity of Phenol‑Rich Fraction of Piper sylvaticum Roots

   Akash Ved, Amresh Gupta, Om Prakash, Ajay Kumar Singh Rawat

   pp. 339–342 · DOI: 10.4103/pr.pr_125_17 · Published

   Obective:Piper sylvaticumRoxb. is an important folk medicine in Indian Traditional System of Medicine widely used by different tribes in many countries. In the present study, the anticonvulsant activity of extract/fracti…

3. Article

   The Effect of Capsicum Oleoresin on Nitric Oxide Production and Nitric Oxide Synthase Gene Expression in Macrophage Cell Line

   Srinivasan Manthra Prathoshni, Roy Anitha, Thangavelu Lakshmi

   pp. 343–346 · DOI: 10.4103/pr.pr_46_18 · Published

   Background:Nitric oxide (NO) is an inflammatory agent produced by macrophages. It also acts as a neurotransmitter. However, overproduction of NO results in acute or chronic inflammation. Capsicum is well known for its an…

4. Article

   Study of Glucose Uptake Enhancing Potential of Fenugreek (Trigonella foenum graecum) Leaves Extract on 3T3 L1 Cells Line and Evaluation of its Antioxidant Potential

   Debarupa Hajra, Santanu Paul

   pp. 347–353 · DOI: 10.4103/pr.pr_50_18 · Published

   Background:The incidence of diabetes mellitus (DM) is increasing at an alarming rate globally. There is a need for suitable natural alternatives for its treatment, as the regular use of drugs causes several secondary hea…

5. Article

   Zingiber zerumbet Rhizomes Extract Exhibits Faster Open Wound Healing in Rats

   Asmah Hamid, Chong Pek Lian, Nur Hafiza Salleh Hudin, Ahmad Rohi Ghazali, Nurul Farhana Jufri

   pp. 354–360 · DOI: 10.4103/pr.pr_14_18 · Published

   Background: Zingiber zerumbetrhizome ethyl acetate extract (ZZRE) has the potential to be developed as a wound‑healing agent with its profound anti‑inflammatory property. Objective:This study was conducted to evaluate th…

6. Article

   In vitro Antioxidant and Antidiabetic Activity of Oligopeptides Derived from Different Mulberry (Morus alba L.) Cultivars

   Suchisree Jha, Saran Kumar Gupta, Phalguni Bhattacharyya, Amitava Ghosh, Palash Mandal

   pp. 361–364 · DOI: 10.4103/pr.pr_70_18 · Published

   Background: Several plant peptides have been known to exhibit various pharmacological activities. However, the bioactivity of mulberry peptides is not yet reported. Objective: In the present study, the peptides from diff…

7. Article

   HPLC-DAD-ESI-MS/MS Characterization of Bioactive Secondary Metabolites from Strelitzia nicolai Leaf Extracts and Their Antioxidant and Anticancer Activities In vitro

   Mosad Ghareeb, Amal Saad, Wafaa Ahmed, Laila Refahy, Sami Nasr

   pp. 368–378 · DOI: 10.4103/pr.pr_89_18 · Published

   Background: Strelitzia nicolai Regel and Körn (Strelitziaceae) is native to Southern Africa whose phytochemistry and pharmacology were slightly investigated. Materials and Methods:In the current work, different solvent e…

8. Article

   Solubility of Calcium Oxalate and Calcium Phosphate Crystallization in the Presence of Crude Extract and Fractions from Kelussia odoratissima Mozaff

   Akram Torki, Tahereh Hosseinabadi, Sheida Fasihzadeh, Arezo Sadeghimanesh, Joko Priyanto Wibowo, Zahra Lorigooini

   pp. 379–384 · DOI: 10.4103/pr.pr_68_18 · Published

   Background and Aim: Urinary tract stones are the third common urinary tract disease that may lead to renal failure. Kelussia odoratissima is traditionally used in the treatment of kidney stones in Chaharmahal va Bakhtiar…

9. Article

   Antioxidant and α‑Glucosidase Inhibitory Activities and Gas Chromatography–Mass Spectrometry Profile of Salak (Salacca zalacca) Fruit Peel Extracts

   Mohammed S. M. Saleh, Mohammad Jamshed Siddiqui, Siti Z. Mat So’ad, Suganya Murugesu, Alfi Khatib, Mokhlesur M. Rahman

   pp. 385–390 · DOI: 10.4103/pr.pr_7_18 · Published

   Background: Salacca zalaccaor better known as salak fruit is widely distributed in tropical and subtropical countries, and it is traditionally used to treat diabetes. This study was aimed to investigate the salak peel ex…

10. Article

    Protective Effect of Ferulago angulata (Schltdl.) Boiss. Hydroalcoholic Extract against Acetic Acid‑induced Colitis in Rat: Role of Pro‑inflammatory Cytokines

    Fatemeh Farzaei, Fatemeh Heydarpour, Mohammad Hosein Farzaei, Zahra Minush Siavash Haghighi, Zahra Abbasabadi, Ehsan Sadeghi

    pp. 391–396 · DOI: 10.4103/pr.pr_9_18 · Published

    Background: Ulcerative colitis (UC) is a chronic recurrent inflammatory disease with unknown etiology. Ferulago angulata(Schltdl.) Boiss. has been proposed as an efficacious treatment for gastrointestinal ulcers and UC i…

11. Article

    In vitro Assessment of Antioxidant, Antimicrobial, Cytotoxic, Anti‑inflammatory, and Antidiabetic Activities of Campanula retrorsa Crude Extracts

    Josiane Alhage, Hoda Elbitar, Samir Taha, Thierry Benvegnu

    pp. 397–403 · DOI: 10.4103/pr.pr_73_18 · Published

    Background:Campanula retrorsa belongs to the Campanulaceae family and the Campanula genus. The species of this latter are traditionally known for their antiallergic, spasmolytic, antiphlogistic, antioxidant, and antivira…

12. Article

    Seabuckthorn (Hippophae rhamnoides and Hippophae salicifolia) Seed Oil in Combating Inflammation: A Mechanistic Approach

    Suchita Dubey, M. V. Ramana, Anuradha Mishra, Pushpraj S. Gupta, Himani Awasthi

    pp. 404–407 · DOI: 10.4103/pr.pr_71_18 · Published

    Objective:This study assessed and comparedin vivoanti‑inflammatory activity of Hippophae rhamnoides (HR) andHippophae salicifolia (HS) seed oil. Materials and Methods:HR and HS seed oil was extracted by Soxhlet apparatus…

13. Article

    Evaluation of Toxicological, Diuretic, and Laxative Properties of Ethanol Extract from Macrothelypteris Torresiana (Gaudich) Aerial Parts with In silico Docking Studies of Polyphenolic Compounds on Carbonic Anhydrase II: An Enzyme Target for Diuretic Acti

    Sumanta Mondal, Naresh Panigrahi, Purab Sancheti, Ruchi Tirkey, Prasenjit Mondal, Sara Almas, Venu Kola

    pp. 408–416 · DOI: 10.4103/pr.pr_16_18 · Published

    Background: Macrothelypteris torresiana (Gaudich) is a species of fern having a wide range of reputed medicinal properties for the treatment of inflammation, fever, renal failure, stomach problems, etc. Objective:The pre…

14. Article

    In vitro Assessment of Antioxidant and Antiurolithic Activities of Ethanol Extract of Whole Plant Biophytum sensitivum (Linn.) DC

    B. R. Abhirama, Shanmugasundaram Rajagopal, I. S. Neethu, S. G. Ariya, B. Athira, K. M. Dhanalekshmi

    pp. 417–421 · DOI: 10.4103/pr.pr_30_18 · Published

    Background:Previous research studies have demonstrated that the formation of urinary stones leads to oxidative stress in patients; hence, search for antiurolithic drugs possessing antioxidant activities from natural sour…

15. Article

    Validation of High‑Performance Liquid Chromatography Method for Quantification of Costunolide Content in Laurus nobilis

    Puttaswamy Naveen, Harakanahalli Basavegowda Lingaraju, Siddappa Chandrappa, Koretekera Shekharappa Priya, Kodimule Shyam Prasad

    pp. 422–425 · DOI: 10.4103/pr.pr_31_18 · Published

    Objective:To establish a method to determine the content of costunolide in Laurus nobilis leaves by high‑performance liquid chromatography (HPLC). Materials and Methods: The separation was performed on a reversed‑phase C…

16. Article

    Oral Intake of Polyphenols of Chromolaena odorata: A Perspective in Peptic Ulcer, Thrombocytopenia, and Heparin‑induced Bleeding Diathesis in Rodent Model

    Tania S. Paul, Biswadeep B. Das, Shakti P. Ingale, Niruta Killedar, Kishori G. Apte

    pp. 426–431 · DOI: 10.4103/pr.pr_107_18 · Published

    Objective:Bleeding disorder is of two types: external bleeding due to trauma, surgery, and internal bleeding which happens mainly due to ulcers and thrombocytopenia or use of excessive anticoagulants. Proven hemostatic a…

17. Article

    The Study of Safety and Skin Whitening Efficacy of Melinjo (Gnetum gnemon L.) Seed Extract‑Loaded Lipid Particle Gel

    Imalia Nurrachma Ayuningtyas, Abdul Mun’im, Sutriyo Sutriyo

    pp. 432–436 · DOI: 10.4103/pr.pr_17_18 · Published

    Background: Melinjo (Gnetum gnemon L.) seed extract (MSE) is potential as skin‑whitening agent because it contains trans‑resveratrol and its derivatives, to inhibit tyrosinase in melanogenesis process. Using MSE in cosme…

18. Article

    Effect of Capsaicin on Pharmacodynamic and pharmacokinetics of Gliclazide in Animal models with Diabetes

    Umachandar Lagisetty, Habibuddin Mohammed, Sivakumar Ramaiah

    pp. 437–441 · DOI: 10.4103/pr.pr_81_18 · Published

    Background: Food–drug interactions can have great effect on the adverse effects of many drugs and also on the success of drug treatment. Gliclazide is one of the drugs of choice to treat type 2 diabetes. Capsaicin is pre…