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    Article

    Effect of Plain and Fortified Amla Fruit Powder on Aluminum‑induced Alzheimer’s Disease in Wistar Rats

    Thonangi Chandi Vishala1★, Gummalla Pitchaiah2, D Pravadha1, Akula Annapurna1★ Corresponding author

    1. 1Division of Pharmacology, A. U. College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, Andhra Pradesh, INDIA.
    2. 2Hindu College of Pharmacy, Guntur, Andhra Pradesh, INDIA.

    CORRESPONDENCE

    Thonangi Chandi Vishala

    Division of Pharmacology, A. U. College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, Andhra Pradesh, INDIA.

    chandivishala@yahoo.com

    Volume 11, Issue 4 · pp. 406–409 · PUBLISHED · DOI: 10.4103/pr.pr_17_17

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Objectives: The present study was designed to evaluate the antioxidant and Nootropic activities of Emblica officinalis against aluminum‑induced Alzheimer’s disease (AD) in Wistar rats. Materials and Methods: Alzheimer’s was induced using aluminum chloride at a dose of 4.2 mg/kg by intraperitoneal route for 28 days. In prophylactic studies, the plain amla powder (500 mg/kg) and fortified amla powder (300 mg/kg) were administered along with the aluminum chloride. In the curative study, the fortified amla powder (500 mg/kg) was administered to Alzheimer’s‑induced rats. Memory impairment was confirmed by measuring the nootropic activity using Morris water maize. At the end of the treatment, the oxidative stress parameters such as malondialdehyde (MDA), superoxide dismutase (SOD), and catalase were evaluated. Results: The present study showed statistically significant increase in nootropic activity in terms of decrease in latency period in treatment groups when compared with the controlled Alzheimer’s‑induced group. The administration of amla fruit powder (plain and fortified) decreased the MDA levels and increased the SOD and catalase levels. Conclusion: The present study proved that E. officinalis is a promising tool in antioxidant and neuroprotective activity against aluminum chloride‑induced AD.

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      Vishala, T. C., Pitchaiah, G., Pravadha, D., & Annapurna, A. (). Effect of Plain and Fortified Amla Fruit Powder on Aluminum‑induced Alzheimer’s Disease in Wistar Rats. Pharmacognosy Research, 11(4), 406–409. https://doi.org/10.4103/pr.pr_17_17