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    Phytochemical and Pharmacological Screening of Begonia grandis Dryand

    Srinivasarao Pendy1, Krishna Nallamothu1, Ganapaty Seru2★, Sunitha Katta2, Sumanta Mondal2★ Corresponding author

    1. 1Research and Development Wing, Divis Laboratories Ltd, Visakhapatnam, Andhra Pradesh, INDIA.
    2. 2GITAM Institute of Pharmacy, GITAM (Deemed to be University), Visakhapatnam, Andhra Pradesh, INDIA.

    CORRESPONDENCE

    Ganapaty Seru

    GITAM Institute of Pharmacy, GITAM (Deemed to be University), Visakhapatnam, Andhra Pradesh, INDIA.

    ganapatyseru@gmail.com

    Received: 08-07-2020; Revised: 15-07-2020; Accepted: 15-09-2020.

    Volume 12, Issue 4 · pp. 375–379 · PUBLISHED · DOI: 10.4103/pr.pr_67_20

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Begonia grandis Dryand (Family: Begoniaceae) was screened for its phytoconstituents and evaluated for its ethnomedicinal potential as an antioxidant and hepatoprotective agent. The preliminary phytochemical studies of the B. grandis revealed the presence of alkaloids, flavonoids, glycosides, triterpenoids, and steroids. Antioxidant effect of the methanolic extract was assessed by DPPH, superoxide, hydroxyl radical scavenging activity, and hepatoprotective effect by CCl4-induced hepatotoxicity. The extract showed significant antioxidant and hepatoprotective effects at a dose of 400 mg/kg similar to that observed in ascorbic acid and silymarin.

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      Pendy, S., Nallamothu, K., Seru, G., Katta, S., & Mondal, S. (). Phytochemical and Pharmacological Screening of Begonia grandis Dryand. Pharmacognosy Research, 12(4), 375–379. https://doi.org/10.4103/pr.pr_67_20