Development of a Solid Self-emulsifying Drug Delivery System of Boswellia serrata
Vidhi Bhatia1★, MS Arohi Paul1★ Corresponding author
- 1Vivekanand Education Society’s College of Pharmacy Chembur, Mumbai, Maharashtra, INDIA.
CORRESPONDENCE
Vidhi Bhatia
Vivekanand Education Society’s College of Pharmacy Chembur, Mumbai, Maharashtra, INDIA.
Received: 12-07-2022; Revised: 25-08-2022; Accepted: 05-09-2022.
Volume 14, Issue 4 · pp. 429–441 · PUBLISHED · DOI: 10.5530/pres.14.4.63
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ABSTRACT
Background:Self-emulsifying drug delivery system (SEDDS) and solid-SEDDS of Boswellia serrataextract (BSE) was aimed at overcoming the problems of poor solubility and bioavailability. Materials and Methods:The formulation strategy included a selection of oil phase, surfactant and co-surfactant based on qualitative and quantitative saturated solubility studies. A ternary phase diagram was constructed to identify the self-emulsifying region using water uptake studies. Pseudoternary phase diagrams were plotted using 1:1, 2:1 and 3:1 ratios of surfactant and co-surfactant to identify the maximum micro-emulsification region. The prepared formulations of SEDDS were evaluated for their physical appearance, stability, drug content, and globule size determination. Solid-SEDDS were prepared by adsorption technique using mannitol (4.5% w/w) and were evaluated for physical appearance, stability, drug content, and globule size. In-vitrostudies were performed to compare the release of solid drugs, SEDDS and S-SEDDS. Results:The formulation containing Boswellia serrata(200 mg), Capmul MCM C8 (15% w/w), Tween 20 (33.333% w/w), Transcutol HP (16.666% w/w) was concluded to be optimized. The release pattern was signified more than 80% release in 30 min in case of S-SEDDS and SEDDS, and 40% release after 120 min in case of solid drug. Solid-SEDDS may be considered a better solid oral dosage form as solidified formulations are more ideal than liquid ones in terms of their stability. Conclusion:Results suggest the potential use of SEDDS and solid-SEDDS to improve the dissolution and hence oral bioavailability of poorly water-soluble drugs like Boswellia serratathrough oral route.
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Bhatia, V., & Paul, M. A. (). Development of a Solid Self-emulsifying Drug Delivery System of Boswellia serrata. Pharmacognosy Research, 14(4), 429–441. https://doi.org/10.5530/pres.14.4.63