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    Anti-atherogenic and Synergistic Effect of Decosapentanoic Acid/Linoleic Acid Fatty Acids via Janus Kinase [JAK] Mediate Inhibition of HMG-CoA Reductase in Rats Fed High Fat Diet

    Etimad Huwait1,2, Taha Abdullah Kumosani1,2,3, Said Salama Moselhy4★★ Corresponding author

    1. 1Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, SAUDI ARABIA.
    2. 2Experimental Biochemistry Unit, King Fahd Medical Research Center, King Abdulaziz University Jeddah, SAUDI ARABIA.
    3. 3Production of Bio-products for Industrial Application Research Group, King Abdulaziz University, Jeddah, SAUDI ARABIA.
    4. 4Department of Biochemistry, Faculty of Science, Ain Shams University, Cairo, EGYPT.

    CORRESPONDENCE

    Said Salama Moselhy

    Department of Biochemistry, Faculty of Science, Ain Shams University, Cairo, EGYPT.

    moselhy6@hotmail.com

    Received: 22-09-2023; Revised: 31-10-2023; Accepted: 09-11-2023.

    Volume 16, Issue 1 · pp. 152–155 · PUBLISHED · DOI: 10.5530/pres.16.1.19

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Introduction: Atherosclerosis is common CHD caused by accumulation of oxidized LDL-c forming foam cell with macrophage that narrowing blood vessels. It increased risk of CVD. Green vegetables rich with PUFA is important to maintain healthy status. This study investigated the mechanistic pathway mediate combination of Decosapentanoic acid (DPA) and linoleic acid (LA) as anti-atherothengic effect in rats fed high fat diet.Materials and Methods: Seventy-five male albino rats were divided into five groups (15 rats each) were fed high fat diet (40% Saturated fat) for 3 months: Group (I): Rats given 10 % DPA. Group (II): Rats given 10 % LA. Group (III): Rats given 10 % DPA+10% LA. Group (IV): Rats treated with atorvastatin (10 mg/kg BW) and Group (v) Untreated. In addition, Group (VI): 15 rats fed normal diet. Results: Data obtained showed that, plasma cholesterol and LDL-c levels were highly significant reduced in group III (p < 0.001) versus other groups compared with untreated. Level of triglycerides was reduced but still high than normal (p=0.05) and atherogenic index. The activity of HMG-CoA reductase was reduced while apo-A, apo-c elevated, JAK was upregulated in combination therapy (p< 0.001). The elevated Apo-A, apo-c activate clearing factor and decreased triglycerides. Conclusion:It was concluded that, upregulated of JAK by combination therapy mediate inhibition of HMG-CoA reductase that decreased endogenous synthesis of cholesterol and reduced its level in circulation.

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      Huwait, E., Kumosani, T. A., & Moselhy, S. S. (). Anti-atherogenic and Synergistic Effect of Decosapentanoic Acid/Linoleic Acid Fatty Acids via Janus Kinase [JAK] Mediate Inhibition of HMG-CoA Reductase in Rats Fed High Fat Diet. Pharmacognosy Research, 16(1), 152–155. https://doi.org/10.5530/pres.16.1.19