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    Investigating Dioscorea polystachya Starch as a Pharmaceutical Excipient

    Vijayan Venugopal1★, Jaiganesh Krishnan2, Lim Hui Feng3, Ang Li Ni3, Venkates Kumar3, Gunasunderi Raju4★ Corresponding author

    1. 1School of Pharmacy, Sri Balaji Vidyapeeth (Deemed to be University), Puducherry, INDIA.
    2. 2Department of Physiology, Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidyapeeth (Deemed to be University), Puducherry, INDIA.
    3. 3Department of Pharmaceutical Technology, Faculty of Pharmacy, Asian Institute of Medical Science and Technology (AIMST) University, Kedah, MALAYSIA.
    4. 4School of Distance Education, Universiti Sains Malaysia, Pulau Pinang, MALAYSIA.

    CORRESPONDENCE

    Vijayan Venugopal

    School of Pharmacy, Sri Balaji Vidyapeeth (Deemed to be University), Puducherry, INDIA.

    vijayanv2@gmail.com

    Received: 18-04-2024; Revised: 04-06-2024; Accepted: 14-06-2024.

    Volume 16, Issue 4 · pp. 784–792 · PUBLISHED 1 October 2024 · DOI: 10.5530/pres.16.4.90

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Background: Dioscorea polystachya (DP) starch, a low-cost, abundant, renewable and degradable starch, is being explored as a potential pharmaceutical excipient for drug formulation.Objectives: This study aimed to explore and isolate starch from Dioscorea polystachya and evaluate the excipients' properties.Materials and Methods: To study the phytochemical, physicochemical, morphological, rheological and emulsifying properties.Results:The isolated matter yields 40.5% starch from its dry weight of tubers and contains carbohydrates, moisture, lipids, nitrogen and various minerals. DP starch has 22.58±0.22% amylose and exhibits a non-Newtonian flow behaviour. The emulsifying capacity improved with the increasing starch concentration and provided significant emulsion stability through different oil ratios to polysaccharide solution. It showed an excellent foaming ability; however, foam stability gradually reduced over time .Conclusion: These findings indicate that Dioscorea polystachyastarch provides significant excipient properties so that it could be used as an excipient in the pharmaceutical industry.

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      Venugopal, V., Krishnan, J., Feng, L. H., Ni, A. L., Kumar, V., & Raju, G. (2024). Investigating Dioscorea polystachya Starch as a Pharmaceutical Excipient. Pharmacognosy Research, 16(4), 784–792. https://doi.org/10.5530/pres.16.4.90