Evaluating the Efficacy of a Ginger Extract-Infused Mustard Oil Transdermal Patch for Arthritis Management

ABSTRACT

Aim: The aim of this study is to develop and characterize a novel herbal transdermal patch containing mustard oil and ginger extract for the management of arthritis, addressing the significant pain and reduced quality of life associated with this chronic inflammatory condition. Materials and Methods:Various extraction methods, including water, alcohol, and mustard oil extraction, were employed to obtain ginger extract. These extracts underwent initial evaluation and subsequent in vitro anti-inflammatory testing. Transdermal patch formulations were developed using the oil-based ginger extract, with naproxen incorporated as a model drug. Parameters such as weight variations, folding endurance, tensile strength, and moisture content were rigorously assessed. In vitro drug permeability tests and ex vivo permeation tests were conducted to evaluate drug release characteristics, with Rhodamine B/Oil Red O Dye used as a tracer. Results: Water-extracted ginger showed reduced potency on the 14th day with some fungal growth, while the alcohol extract exhibited lower efficacy compared to the oil extract. Six distinct transdermal patch formulations were developed, with parameters such as weight variations, folding endurance, tensile strength, and moisture content meeting specified criteria. In vitro drug permeability tests and ex vivo permeation tests revealed a drug release range of 0.1 to 0.3 mm, a moisture content of 3%, a tensile strength of 1 pascal, and a drug release rate of 90%.Conclusion:The study demonstrates the successful development and characterization of a novel herbal transdermal patch containing mustard oil and ginger extract for arthritis management. Despite challenges with water-extracted ginger and lower efficacy of the alcohol extract, the oil-based ginger extract showed promising results. The formulated transdermal patch exhibited favourable drug release characteristics and can potentially offer an effective therapeutic option for arthritis patients.

KEYWORDS

• Anti-arthritic Activity
• Docking study
• Ginger-mustard extraction
• Transdermal patches

Showing references and in-text citations exactly as published.

• DOI10.5530/pres.16.4.107Copy

RELATED ARTICLES

Matched on section and article type within this issue of Pharmacogn. Res..

• Article · VOLUME 16, ISSUE 4Screening of in vitro Anticancer Activity of Various Human Cancer Cell Lines and Induced Apoptosis and Cell Arrest by Ethanolic Bulb Extract of Pancratium zeylanicumElumalai Shanthi Priya, Devaraj Sathiya Sheela, Devaraj Sheeba Gnanadeebam, Balrajmani Davidson Raja, Periannan Viswanathan · pp. 718–726Research ArticleSame type: Article
• Article · VOLUME 16, ISSUE 4Phytochemical Analysis of Selected Indigenous Plants and Essential Oils by Gas Chromatography/Mass Spectrometry Dedicate Antibacterial, Anti-Proliferative and Anti-Inflammatory ActivityFatma A. Eissa, Taha A. Kumosani, Elie K. barbour, Nouf O. Alshareef, Khalid M. El-Say, Said S. Moselhy · pp. 727–732Research ArticleSame type: Article
• Article · VOLUME 16, ISSUE 4Evaluation of Balya Activity of Atibala (Abutilon indicum (Linn.) Sw) in Cisplatin-Induced Muscle Atrophy ModelVishala Hiremath, Vedantam Giridhar, Santosh F Patil, Ranjit Kangle · pp. 733–740Research ArticleSame type: Article
• Article · VOLUME 16, ISSUE 4Comprehensive Phytochemical Profiling and Antiphage Activity of Methanolic Extract of Withania somnifera against Lactic Acid BacteriophagesMulay Rutam, Zarine P Bhathena · pp. 741–747Research ArticleSame type: Article