Evaluation of Wound Healing Activity of Polyherbal Gel Containing Azadirachta indica, A. Juss. and Tridax procumbens L. Extracts

ABSTRACT

Background: Azadirachta indicaA. Juss. and Tridax procumbens L. have been utilized for wound management and therapy since ancient times and offer huge potential.Objectives: To formulate polyherbal gel containing Azadirachta indicaA. Juss. and Tridax procumbens L. and to evaluate it further in wound management. Materials and Methods:In this study, three polyherbal formulations of Azadirachta indicaA. Juss. and Tridax procumbens L. with varied proportions of both plants were formulated and appearance, nature, grittiness, phase separation, pH, viscosity and extrudability of all prepared formulations were compared with control, standard (Betadine 5%) and individual formulations of these plants. Excision wound model was used to study wound healing action of prepared formulation. Results:Formulation with Azadirachta indica A. Juss. and Tridax procumbence L. extracts in equal proportion showed the best results in formulation parameters. The rate of wound contraction, tensile strength, epithelialization rate, and hydroxyproline content of the wound were used to determine the rate of wound healing. According to the results, there was an increase in wound contraction as well as an increase in wound strength for this formulation. Correlations between hydroxyproline expression and healing patterns were also found in histopathology, it was observed that the wounds treated with an equal proportion of plant extract and betadine minimized scar formation and improved fibroblast proliferation, angiogenesis, keratinization, and epithelialization.Conclusion:As per the different physical, histological, and biochemical parameters, hydroalcoholic extract of Azadirachta indica A. Juss. and Tridax procumbens L. in equal proportions showed good wound healing activity.

KEYWORDS

• Azadirachta Indica A. Juss
• in vivo evaluation of formulation
• Polyherbal Gel Formulation
• Tridax procumbens L
• Wound healing

Showing references and in-text citations exactly as published.

• DOI10.5530/pres.16.4.110Copy

RELATED ARTICLES

Matched on section and article type within this issue of Pharmacogn. Res..

• Article · VOLUME 16, ISSUE 4Screening of in vitro Anticancer Activity of Various Human Cancer Cell Lines and Induced Apoptosis and Cell Arrest by Ethanolic Bulb Extract of Pancratium zeylanicumElumalai Shanthi Priya, Devaraj Sathiya Sheela, Devaraj Sheeba Gnanadeebam, Balrajmani Davidson Raja, Periannan Viswanathan · pp. 718–726Research ArticleSame type: Article
• Article · VOLUME 16, ISSUE 4Phytochemical Analysis of Selected Indigenous Plants and Essential Oils by Gas Chromatography/Mass Spectrometry Dedicate Antibacterial, Anti-Proliferative and Anti-Inflammatory ActivityFatma A. Eissa, Taha A. Kumosani, Elie K. barbour, Nouf O. Alshareef, Khalid M. El-Say, Said S. Moselhy · pp. 727–732Research ArticleSame type: Article
• Article · VOLUME 16, ISSUE 4Evaluation of Balya Activity of Atibala (Abutilon indicum (Linn.) Sw) in Cisplatin-Induced Muscle Atrophy ModelVishala Hiremath, Vedantam Giridhar, Santosh F Patil, Ranjit Kangle · pp. 733–740Research ArticleSame type: Article
• Article · VOLUME 16, ISSUE 4Comprehensive Phytochemical Profiling and Antiphage Activity of Methanolic Extract of Withania somnifera against Lactic Acid BacteriophagesMulay Rutam, Zarine P Bhathena · pp. 741–747Research ArticleSame type: Article