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    Review

    A Comprehensive Review on Medicinal Herbal Plant with Potential Hypolipidemic Activity

    Devendra Dhanorya1, Vikas Pnadey1, Rajesh Shukla1, Yuvraj Vishwakarma1, Gourav Kumar Bairagi1, Vandana Gupta1, Pushpender Bardiya2, Shivam Kumar Kori1, Priyansh Patel4, Nishant Kumar Bardiya3, Shikha Bhalla5, Shubham Anand6★★ Corresponding author

    1. 1Department of Pharmacy, Mangalayatan University, Jabalpur, Madhya Pradesh, INDIA.
    2. 2Department of Pharmacy, Major S.D. Singh University, Farrukhabad, Uttar Pradesh, INDIA.
    3. 3Department of Pharmacy, Adina College of Pharmacy, Sagar, Madhya Pradesh, INDIA.
    4. 4Department of Pharmacy, Guru Ramdas Khalsa Institute of Sciences and Technology Pharmacy, Jabalpur, Madhya Pradesh, INDIA.
    5. 5Department of Pharmacy, Gyanveer College of Pharmacy, Madhya Pradesh INDIA.
    6. 6Department of Pharmacology, School of Pharmacy, ITM University, Gwalior, Madhya Pradesh, INDIA.

    CORRESPONDENCE

    Shubham Anand

    Department of Pharmacology, School of Pharmacy, ITM University, Gwalior, Madhya Pradesh, INDIA.

    anandshubham582@gmail.com

    Received: 06-11-2024; Revised: 11-11-11; Accepted: 17-12-2024.

    Volume 17, Issue 2 · pp. 489–506 · PUBLISHED 2025 · DOI: 10.5530/pres.20252009

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Hyperlipidaemia, characterized by elevated blood lipid levels, is a significant risk factor for cardiovascular diseases. While traditional pharmacological treatments are available, their effectiveness and potential side effects highlight the need to explore alternative approaches. Herbal plants have attracted attention due to their variety of bioactive compounds with therapeutic potential. This review aims to provide an overview of the lipid-lowering effects of several herbal plants, discussing their mechanisms of action and available clinical evidence. Notable herbs such as garlic (Allium sativum), ginger (Zingiber officinale) and green tea (Camellia sinensis) have shown potential in reducing lipid levels by modulating enzymes involved in lipid metabolism, inhibiting cholesterol absorption and enhancing lipid excretion. The findings suggest that numerous phytochemicals may offer therapeutic benefits for managing hyperlipidaemia. In addition, an analysis of 83 compounds indicates that 60 adhere to Lipinski’s Rule of Five and Veber’s Rule, suggesting that these compounds possess optimal physicochemical properties, which could make them viable candidates for future treatments of hyperlipidaemia.

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      Dhanorya, D., Pnadey, V., Shukla, R., Vishwakarma, Y., Bairagi, G. K., Gupta, V., Bardiya, P., Kori, S. K., Patel, P., Bardiya, N. K., Bhalla, S., & Anand, S. (2025). A Comprehensive Review on Medicinal Herbal Plant with Potential Hypolipidemic Activity. Pharmacognosy Research, 17(2), 489–506. https://doi.org/10.5530/pres.20252009