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    Pharmacognosy ResearchNOW IN
    Article

    Antioxidant, Stimulating Telomerase and Anxiolytic Activities of Polysaccharide Isolated from Sargentodoxa cuneata

    Jian Tang1,2★, Ping Zhou1, Huifang Sun3, Xiuquan Xu1,2, Chongwei Wen3, Haiping Xia4★ Corresponding author

    1. 1School of Chinese Medicine, Bozhou University, Bozhou, CHINA.
    2. 2Key Laboratory of Chinese Medicine Materials Research of Anhui Higher Education Institutes, Bozhou University, Bozhou, CHINA.
    3. 3School of Pharmacy, Jiangsu University, Zhenjiang, CHINA.
    4. 4Department of Neurology, The Affiliated Fourth People's Hospital of Jiangsu University, Zhenjiang, CHINA.

    CORRESPONDENCE

    Jian Tang

    1,2, 1School of Chinese Medicine, Bozhou University, Bozhou-236800, CHINA. 2Key Laboratory of Chinese Medicine Materials Research of Anhui Higher Education Institutes, Bozhou University, Bozhou-236800, CHINA.

    jt.u@hotmail.com

    Received: 28-02-2025; Revised: 14-04-2025; Accepted: 03-06-2025.

    Volume 17, Issue 3 · pp. 1020–1028 · PUBLISHED Jul-Sep 2025 · DOI: 10.5530/pres.20252269

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Background The classic anxiolytics have adverse effects in the treating anxiety disorders. Aim To identify the anxiolytic polysaccharide from Sargentodoxa cuneata. Materials and Methods The water-soluble Polysaccharide Fraction (PSC) was purified from S. cuneata, as well as its subfractions PSCA-1 and PSCB-1. The antioxidant effect of PSC against rotenone induced PC12 cell excitotoxicity, stimulating telomerase effect in HEK293T cell and anxiolytic effect on zebrafish were evaluated. Results The pretreatment of PC12 with PSC obviously increased cell survival and SOD level. PSC also down-regulated the LDH release, ROS level and cell apoptosis rate. PSC promoted the 293T cell proliferation, associated with the mechanism of stimulating telomerase. Additionally, PSC alleviated the anxiety level in zebrafish induced by mCPP. Conclusion These findings suggested that the PSC could possess the anxiolytic potential via antioxidant and telomerase activation.

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      Tang, J., Zhou, P., Sun, H., Xu, X., Wen, C., & Xia, H. (2025). Antioxidant, Stimulating Telomerase and Anxiolytic Activities of Polysaccharide Isolated from Sargentodoxa cuneata. Pharmacognosy Research, 17(3), 1020–1028. https://doi.org/10.5530/pres.20252269