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    Review

    Phytoflavonoids-A Future Perspective for the Therapeutic Potential of Alzheimer’s Disease

    Karthigadevi Kamalakannan1, Shanmuganathan Seetharaman2★, Anbazhagan Sockalingam3, K Reeta VijayaRani3, Kavimani Subramanian4★ Corresponding author

    1. 1School of Pharmacy, Sri Balaji Vidyapeeth (Deemed to be University), Pillaiyarkuppam, Puducherry, India and Department of Pharmacology, Surya School of Pharmacy, Surya Group of Institutions, Vikravandi, Villupuram, Tamil Nadu, INDIA.
    2. 2Department of Pharmaceutics, School of Pharmacy, Sri Balaji Vidyapeeth Deemed to be University, Pillaiyarkuppam, Puducherry, INDIA.
    3. 3Surya School of Pharmacy, Surya Group of Institutions, Vikravandi, Villupuram, Tamil Nadu, INDIA.
    4. 4Department of Pharmacology, College of Pharmacy, Mother Theresa Postgraduate and Research Institute of Health Sciences, Indira Nagar, Gorimedu, Puducherry, INDIA.

    CORRESPONDENCE

    Shanmuganathan Seetharaman

    Principal, Department of Pharmaceutics, School of Pharmacy, Sri Balaji Vidyapeeth (Deemed to be University), Pillaiyarkuppam, Puducherry, INDIA.

    shanmuganathan@sbvu.ac.in

    Received: 29-01-2025; Revised: 25-03-2025; Accepted: 03-06-2025.

    Volume 17, Issue 3 · pp. 788–795 · PUBLISHED Jul-Sep 2025 · DOI: 10.5530/pres.20252213

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Millions of people suffer from the neurodegenerative diseases like Alzheimer's Disease (AD) worldwide. Due to their complex pathology, no effective pharmacological treatment has been found to date, despite extensive research. Developing new, effective therapeutic agents to cure these disease remains a major challenge. Although the cause of AD remains apparent, numerous studies indicates that oxidative stress and neuro-inflammation lead to neurodegeneration in the central nervous system and play vital role in AD morbidity and progression. Flavonoids, which are found widely in nature, exhibit anti-oxidative, anti-inflammatory, anti-mutative, anti-microbial, and neuroprotective properties, so have potential to treat these two kinds of disease. In this review, we focus on the anti-oxidative and neuroprotective action of flavonoids in attenuating Alzheimer’s disease, and how they might be harnessed in the development of new pharmacological agents to treat these diseases. Some Flavonoids compounds Quercetin, Rutin, hesperidin, Naringinin, Epigallocatechin-3-gallate, displayed to be effective in AD. Considerable studies have demonstrated the anti-AD effects of flavonoids through various in vitro and in vivo models. However, more rigorous studies are needed to be done for flavonoids to develop into effective drugs and apply them to clinical practice.

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      Kamalakannan, K., Seetharaman, S., Sockalingam, A., VijayaRani, K. R., & Subramanian, K. (2025). Phytoflavonoids-A Future Perspective for the Therapeutic Potential of Alzheimer’s Disease. Pharmacognosy Research, 17(3), 788–795. https://doi.org/10.5530/pres.20252213