Phcog.Net logo
Submit

BROWSE ALL JOURNALS

    SEE ALL 6 JOURNALS
    Pharmacognosy ResearchNOW IN
    Article

    Anti-inflammatory activity of aqueous extract of Mirabilis jalapa Linn. Leaves

    Manjit Singh1★, Vijender Kumar1, Ishpinder Singh2, Vinod Gauttam3, Ajudhia Nath Kalia3★ Corresponding author

    1. 1aDepartment of Pharmacognosy, L.L.R. College of Pharmacy, Moga, Punjab-142001
    2. 2Department of Pharmacognosy Adesh College of Pharmacy, Bathinda - 151001, Punjab
    3. 3Department of Pharmacognosy, I.S.F. College of Pharmacy, Moga - 142 001, Punjab, India

    CORRESPONDENCE

    Manjit Singh

    *Address for correspondence: Manjit Singh, Department of Pharmacognosy, L.L.R. College of Pharmacy, Moga - 142 001, Punjab, India.

    2009manjitsingh@gmail.com

    Received: 23-06-2010; Revised: 06-07-2010; Accepted: 12-01-2011.

    Volume 2, Issue 6 · pp. 364–367 · PUBLISHED January 2010 · DOI: 10.4103/0974-8490.75456

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Background The objective of the present study was to evaluate the anti-inflammatory activity of aqueous extract of Mirabilis jalapa Linn. (MJL) (Nyctaginaceae) leaves for scientific validation of the folklore claim of the plant. The leaves are used as traditional folk medicine in the south of Brazil to treat inflammatory and painful diseases. Cosmetic or dermo-pharmaceutical compositions containing MJL are claimed to be useful against inflammation and dry skin. Methods Aqueous extract of the leaves was prepared by cold maceration. Results The anti-inflammatory activity was evaluated using carrageenan and formalin-induced paw edema models in Wistar albino rats. The anti-inflammatory activity was found to be dose dependent in carrageenan-induced paw edema model. The aqueous extract has shown significant (P < 0.05) inhibition of paw oedema, 37.5% and 54.0% on 4th hour at the doses of 200 and 400 mg/kg, respectively. Similar pattern of paw edema inhibition was seen in formalin-induced paw edema model. The maximum percentage inhibition in paw edema was 32.9% and 43.0% on 4th day at the doses of 200 and 400 mg/kg, respectively. Conclusion The results of present study demonstrate that aqueous extract of the leaves possess significant (P < 0.05) anti-inflammatory potential.

    KEYWORDS

    Open in new tab

    REFERENCES

    As published

    Showing references and in-text citations exactly as published.

      Cite this article

      SELECT FORMAT

      Singh, M., Kumar, V., Singh, I., Gauttam, V., & Kalia, A. N. (2010). Anti-inflammatory activity of aqueous extract of Mirabilis jalapa Linn. Leaves. Pharmacognosy Research, 2(6), 364–367. https://doi.org/10.4103/0974-8490.75456