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    Article

    A comparative profile of methanol extracts of Allium cepa and Allium sativum in diabetic neuropathy in mice

    Abhishek Bhanot1, Richa Shri2★★ Corresponding author

    1. 1aAmar Shaheed Baba Ajit Singh Jujhar Singh Memorial (ASBASJSM) College of Pharmacy, BELA, Ropar - 1401 11, Punjab
    2. 2Pharmacognosy Division, Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala - 1470 02, Punjab, India

    CORRESPONDENCE

    Richa Shri

    *Address for correspondence: Dr. Richa Shri, Pharmacognosy Division, Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala - 147 002, Punjab, India

    rshri587@hotmail.com

    Received: 27-07-2010; Revised: 21-09-2010; Accepted: 12-01-2011.

    Volume 2, Issue 6 · pp. 374–384 · PUBLISHED January 2010 · DOI: 10.4103/0974-8490.75460

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Introduction Diabetic Neuropathy (DN) is a major microvascular complication of uncontrolled diabetes. This may result from increased oxidative stress that accompanies diabetes. Hence plants with antioxidant action play an important role in management of diabetes and its complications. Materials and Methods This study was designed to evaluate preventive as well as curative effect of methanol extracts of outer scales and edible portions of two plants with established antioxidant action - Allium cepa and Allium sativum, in induced DN in albino mice. Mice were divided into control, diabetic and test extracts treated groups. Test extracts were administered daily at a dose of 200 mg/kg p.o. for 21 days, in the preventive group prior to onset of DN, and in the curative group after the onset of DN. Hyperalgesia and oxidative stress markers were assessed. STZ-diabetic mice showed a significant thermal hyperalgesia (as assessed by the tail-flick test), indicating development of DN. Results Treatment with test extracts prevented loss in body weight, decreased plasma glucose level, and significantly ameliorated the hyperalgesia, TBARS, serum nitrite and GSH levels in diabetic mice. Conclusion Methanol extract of outer scales of onion has shown most significant improvement; may be due to higher content of phenolic compounds in outer scales of A. cepa.

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      Bhanot, A., & Shri, R. (2010). A comparative profile of methanol extracts of Allium cepa and Allium sativum in diabetic neuropathy in mice. Pharmacognosy Research, 2(6), 374–384. https://doi.org/10.4103/0974-8490.75460