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    Dichlorvos and lindane induced oxidative stress in rat brain: Protective effects of ginger

    Poonam Sharma1, Rambir Singh2★★ Corresponding author

    1. 1Departments of Zoology
    2. 2Biomedical Sciences, Bundelkhand University, Jhansi, Uttar Pradesh, India

    CORRESPONDENCE

    Rambir Singh

    *Address for correspondence: Dr. Rambir Singh, Department of Biomedical Sciences, Bundelkhand University, Jhansi, Uttar Pradesh, India.

    sehrawat_r@yahoo.com

    Revised: 22-08-2011.

    Volume 4, Issue 1 · pp. 27–32 · PUBLISHED October-December 2012 · DOI: 10.4103/0974-8490.91031

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Background Dichlorvos and lindane pesticide causes toxicity in animals including humans. Ginger (Zingiber officinale) is widely used as a culinary medicine in the Ayurvedic system of medicine, possessing a number of pharmacological properties. Objective This study was designed to assess ameliorating effects of ginger juice in dichlorvos and lindane induced neurotoxicity in wistar rats. Materials and Methods Dichlorvos (8.8 mg/kg bw) and lindane (8.8 mg/kg bw) were orally administered alone as well as in combination to adult male and female wistar rats for 14 days followed by the post-treatment of ginger juice (100 mg/kg bw) for 14 days. Lipid peroxidation (LPO), reduced glutathione (GSH), and activities of antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione S-transferase (GST), glutathione reductase (GR), quinine reductase (QR), and protein level were measured to evaluate the toxicity of these pesticides in brain. Results Dichlorvos and lindane administration alone and in combination increased LPO and decreased the GSH level, SOD, CAT, GPx, GST, GR, QR activity, and protein. Oxidative stress due to abnormal production of reactive oxygen species (ROS) is believed to be involved in the toxicities induced by these pesticides. Post-treatment of ginger juice decreased LPO and increased the level of GSH, SOD, CAT, GPx, GST, GR, QR activity and protein in the brain of rats. Conclusions The results indicated that dichlorovos and lindane induced tissue damage was ameliorated by ginger juice.

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      Sharma, P., & Singh, R. (2012). Dichlorvos and lindane induced oxidative stress in rat brain: Protective effects of ginger. Pharmacognosy Research, 4(1), 27–32. https://doi.org/10.4103/0974-8490.91031