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    Effect of Butea monosperma Lam. leaves and bark extracts on blood glucose in streptozotocin-induced severely diabetic rats

    Faiyaz Ahmed1★, N. S. Siddaraju1, M. Harish1, Asna Urooj1★ Corresponding author

    1. 1Department of Studies in Food Science and Nutrition, University of Mysore, Manasagangothri, Mysore, Karnataka, India

    CORRESPONDENCE

    Faiyaz Ahmed

    *Address for correspondence: Dr. Faiyaz Ahmed, Department of Studies in Food Science and Nutrition, University of Mysore, Manasagangothri, Mysore – 570 006, Karnataka, India.

    fayaz_ahmed09@yahoo.co.in

    Revised: 22-08-2011.

    Volume 4, Issue 1 · pp. 33–36 · PUBLISHED October-December 2012 · DOI: 10.4103/0974-8490.91032

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Background Diabetes mellitus is a chronic metabolic disorder that has significant impact on the health, quality of life and life expectancy, as well as on the health care system. Butea monosperma Lam. Kuntze (Fabaceae), commonly known as palash, is widely used in the treatment of various diseases and disorders including diabetes. Materials and Methods The present study was planned to evaluate the antidiabetic effect of aqueous extracts of B. monosperma leaves and bark in streptozotocin-induced severely diabetic rats. The animals were divided into four groups, with each consisting of six rats, viz. control, diabetic control, leaf extract-treated and bark extract-treated groups. Treatment was continued for 6 weeks. The biochemical estimations included blood glucose and serum insulin levels. Histopathology of pancreas was also performed. Results The results indicated that both leaf and bark extracts of B. monosperma produced insignificant antihyperglycemic activity. The leaf and bark extracts reduced blood glucose to an extent of 28% and 11%, respectively. It was also evidenced that both leaf and bark extracts did not increase insulin synthesis or secretion and did not improve pancreatic architecture as reflected by the histopathologic studies. Conclusions The findings of the study emphasize that B. monosperma does not possess significant antidiabetic activity in severe experimental diabetes at the dosage tested.

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      Ahmed, F., Siddaraju, N. S., Harish, M., & Urooj, A. (2012). Effect of Butea monosperma Lam. leaves and bark extracts on blood glucose in streptozotocin-induced severely diabetic rats. Pharmacognosy Research, 4(1), 33–36. https://doi.org/10.4103/0974-8490.91032