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    Antibacterial activity and the histopathological study of crude extracts and isolated tecomine from Tecoma stans Bignoniaceae in Iraq

    Amad M. Al-Azzawi1★, Ekbal Al-Khateeb2, Kulood Al-Sameraei3, Alyaa G. Al-Juboori4★ Corresponding author

    1. 1Ras Al Khaimah College of Pharmaceutical Sciences, Ras Al Khaimah Medical and Health Sciences University, Ras Al Khaimah, UAE
    2. 2Al-Ahliyya Amman University, Jordan
    3. 3Biotechnology Research Center, Al-Nahrain University, Iraq
    4. 4Department of General Education, Ras Al Khaimah Medical and Health Sciences University, Ras Al Khaimah, UAE

    CORRESPONDENCE

    Amad M. Al-Azzawi

    *Address for correspondence: Dr. Amad M. Al-Azzawi, RAK Medical and Health Sciences University, College of Pharmaceutical Sciences, PO Box: 11172, Ras Al Khaimah, United Arab Emirates.

    amadazzawi@yahoo.com

    Revised: 02-08-2011.

    Volume 4, Issue 1 · pp. 37–43 · PUBLISHED October-December 2012 · DOI: 10.4103/0974-8490.91033

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Background Tecoma stans (Bignoniaceae) is a central and south American tree used for the control of diabetes, also known as Yellow Elder, it was collected from the gardens of Al-Jadria in Iraq. Materials and Methods One of the main reported alkaloidal constituents, tecomine, was isolated and confirmed by spectral analysis. The bacteriological assay for different plant leaves extracts; aqueous, ethanolic, and isolated tecomine were conducted to evaluate the antibacterial effect against gram-negative and gram-positive bacteria. Results Whole alcoholic and aqueous extract exhibited the antibacterial activity and isolated tecomine. Histopathological evaluation was demonstrated on the liver, spleen, and pancreas of the BALB/c mice given the whole alcoholic and aqueous extract that showed no significant changes in the organ texture. Conclusion Biochemical analysis of the serum obtained showed decrease in the glucose level in the mice treated with plant extract at the most two higher concentrations used with no change in the cholesterol and triglyceride level.

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      Al-Azzawi, A. M., Al-Khateeb, E., Al-Sameraei, K., & Al-Juboori, A. G. (2012). Antibacterial activity and the histopathological study of crude extracts and isolated tecomine from Tecoma stans Bignoniaceae in Iraq. Pharmacognosy Research, 4(1), 37–43. https://doi.org/10.4103/0974-8490.91033