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    Effect of Coleus forskohlii extract on cafeteria diet-induced obesity in rats

    Hebbani Nagarajappa Shivaprasad1, Sushma Gopalakrishna1★, Bhanumathy Mariyanna1, Midhun Thekkoot1, Roopa Reddy2, Boreddy Shivanandappa Tippeswamy2★ Corresponding author

    1. 1R&D Centre, Olive Lifesciences Pvt. Ltd.
    2. 2Department of Pharmacology, Sree Siddaganga College of Pharmacy, Tumkur, Karnataka, India

    CORRESPONDENCE

    Sushma Gopalakrishna

    *Address for correspondence: Mrs. Sushma Gopalakrishna, Olive Lifesciences Pvt. Ltd., 2203, Pragathi, 16th ‘D’ Cross, 8th Main, ‘D’ Block, Sahakar Nagar, Bangalore - 560 092, Karnataka, India.

    sushma@olivelifesciences.com

    Revised: 18-06-2013.

    Volume 6, Issue 1 · pp. 42–45 · PUBLISHED January-March 2014 · DOI: 10.4103/0974-8490.122916

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Background Obesity is a metabolic disorder that can lead to adverse metabolic effects on blood pressure, cholesterol, triglycerides and insulin resistance and also increases the risk of coronary heart disease, ischemic stroke and type 2 diabetes mellitus. This study was designed to determine the effect of Coleus forskohlii on obesity and associated metabolic changes in rats fed with cafeteria diet. Objective The aim of this study was to evaluate antiobesogenic and metabolic benefits of C. forskohlii in cafeteria diet induced obesity rat model. Materials and Methods Rats were randomly divided into five groups of six animals in each group and as follows: Normal pellet diet group; cafeteria diet group; cafeteria diet followed by 50 mg/kg/d Coleus forskohlii extract (CFE), 100 mg/kg/d CFE and 45 mg/kg/d orlistat groups, respectively. Indicators of obesity such as food intake, body weight and alteration in serum lipid profiles were studied. Results Feeding of cafeteria diet induced obesity in rats. Administration of CFE significantly halted increase in food intake and weight gain associated with cafeteria diet. Development of dyslipidemia was also significantly inhibited. Conclusion The observed effects validate that supplementation of CFE with cafeteria diet could curb the appetite and mitigate the development of dyslipidemia.

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      Shivaprasad, H. N., Gopalakrishna, S., Mariyanna, B., Thekkoot, M., Reddy, R., & Tippeswamy, B. S. (2014). Effect of Coleus forskohlii extract on cafeteria diet-induced obesity in rats. Pharmacognosy Research, 6(1), 42–45. https://doi.org/10.4103/0974-8490.122916