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    Caffeoylquinic acids in leaves of selected Apocynaceae species: Their isolation and content

    Siu Kuin Wong1, Yau Yan Lim1, Sui Kiong Ling2, Eric Wei Chiang Chan3★★ Corresponding author

    1. 1School of Science, Monash University Sunway Campus, Bandar Sunway, 46150 Petaling Jaya, Selangor, Malaysia
    2. 2Natural Products Division, Forest Research Institute Malaysia, Kepong, 52109 Selangor, Malaysia
    3. 3Faculty of Applied Sciences, UCSI University, 56000 Cheras, Kuala Lumpur, Malaysia

    CORRESPONDENCE

    Eric Wei Chiang Chan

    *Address for correspondence: Dr. Eric W.C. Chan, Faculty of Applied Sciences, UCSI University, 56000 Cheras, Kuala Lumpur, Malaysia.

    chanwc@ucsiuniversity.edu.my

    Revised: 15-03-2013.

    Volume 6, Issue 1 · pp. 67–72 · PUBLISHED January-March 2014 · DOI: 10.4103/0974-8490.122921

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Background Three compounds isolated from the methanol (MeOH) leaf extract of Vallaris glabra (Apocynaceae) were those of caffeoylquinic acids (CQAs). This prompted a quantitative analysis of their contents in leaves of V. glabra in comparison with those of five other Apocynaceae species (Alstonia angustiloba, Dyera costulata, Kopsia fruticosa, Nerium oleander, and Plumeria obtusa), including flowers of Lonicera japonica (Japanese honeysuckle), the commercial source of chlorogenic acid (CGA). Materials and Methods Compound were isolated by column chromatography, and identified by NMR and MS analyses. CQA content of leaf extracts was determined using reversed-phase HPLC. Results From the MeOH leaf extract of V. glabra, 3-CQA, 4-CQA, and 5-CQA or CGA were isolated. Content of 5-CQA of V. glabra was two times higher than flowers of L. japonica, while 3-CQA and 4-CQA content was 16 times higher. Conclusion With much higher CQA content than the commercial source, leaves of V. glabra can serve as a promising alternative source.

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      Wong, S. K., Lim, Y. Y., Ling, S. K., & Chan, E. W. C. (2014). Caffeoylquinic acids in leaves of selected Apocynaceae species: Their isolation and content. Pharmacognosy Research, 6(1), 67–72. https://doi.org/10.4103/0974-8490.122921