Phcog.Net logo
Submit

BROWSE ALL JOURNALS

    SEE ALL 6 JOURNALS
    Pharmacognosy ResearchNOW IN
    Article

    Effect of Momordica dioica fruit extract on antioxidant status in liver, kidney, pancreas, and serum of diabetic rats

    Poonam Sharma1, Rambir Singh2★★ Corresponding author

    1. 1Departments of Zoology
    2. 2Biomedical Sciences, Bundelkhand University, Jhansi, Uttar Pradesh, India

    CORRESPONDENCE

    Rambir Singh

    *Address for correspondence: Dr. Rambir Singh, Department of Biomedical Sciences, Bundelkhand University, Kanpur Road, Jhansi - 284 128, Uttar Pradesh, India.

    sehrawat_r@yahoo.com

    Revised: 01-05-2013.

    Volume 6, Issue 1 · pp. 73–86 · PUBLISHED January-March 2014 · DOI: 10.4103/0974-8490.122922

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Background Fruits, leaves, and tuberous roots of Momordica dioica are used as a folk remedy for diabetes mellitus (DM) in India. The aqueous extract of Momordica dioica fruit possesses very good anti-diabetic activity and is having high margin of safety. Objectives The aim of the present study was to investigate the antioxidative effect of Momordica dioica fruits in alloxan-induced diabetic Wistar rats. Materials and Methods Effect of aqueous extract of Momordica dioica (AEMD) on thiobarbituric acid reactive substances (TBARS), hydroperoxide (HP), non-enzymatic and enzymatic antioxidants in liver, kidney, pancreas, and serum was evaluated in diabetic rats after 21 days treatment. Results Increase in the levels of TBARS, HP and decrease in the levels of non-enzymatic antioxidants and activity of enzymatic antioxidants was observed in liver, kidney, pancreas, and serum of diabetic rats when compared with normal healthy rats. TBARS and HP levels were reduced while non-enzymatic and enzymatic antioxidant enzymes activity was increased in AEMD and glibenclamide-treated rats. Furthermore, histological examination of liver, kidney, and pancreas of diabetic rats showed degenerative changes. AEMD treatment for 21 days rejuvenated liver, kidney, and pancreas histoarchitecture. Conclusion In conclusion, the present results showed the protective role of AEMD on liver, kidney, and pancreas in severe diabetic rats justifying support for its anti-diabetic use in folk medicine.

    KEYWORDS

    Open in new tab

    REFERENCES

    As published

    Showing references and in-text citations exactly as published.

      Cite this article

      SELECT FORMAT

      Sharma, P., & Singh, R. (2014). Effect of Momordica dioica fruit extract on antioxidant status in liver, kidney, pancreas, and serum of diabetic rats. Pharmacognosy Research, 6(1), 73–86. https://doi.org/10.4103/0974-8490.122922