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    Evaluation of antiepileptic activity of chloroform extract of Acalypha fruticosa in mice

    Sumalatha Govindu1, Sreedevi Adikay2★★ Corresponding author

    1. 1Department of Pharmacognosy and Phytochemistry, Vaagdevi College of Pharmacy, Hanamkonda
    2. 2Department of Chemistry, Institute of Pharmaceutical Technology, Tirupati, Andhra Pradesh, India

    CORRESPONDENCE

    Sreedevi Adikay

    *Address for correspondence: Prof. A. Sreedevi, Department of Chemistry, Institute of Pharmaceutical Technology, Tirupati, Andhra Pradesh, India.

    sridevitirupati@rediffmail.com

    Revised: 19-09-2013.

    Volume 6, Issue 2 · pp. 108–112 · PUBLISHED April-June 2014 · DOI: 10.4103/0974‑8490.128970

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Aim The aim of the present study is to evaluate the antiepileptic activity of chloroform extract of aerial parts of Acalypha fruticosa in mice. Materials and Methods The antiepileptic activity of chloroform extract of A. fruticosa at the doses of 30, 100 and 300 mg/kg, p.o. was evaluated by maximum electroshock (MES), pentylenetetrazole (PTZ) and isoniazid (INH)-induced convulsions in mice. Statistical analysis was carried out by one-way analysis of variance followed by Dunnett’s test. Results In MES method, the chloroform extract significantly protected the mice from convulsions induced by electroshock method in a dose-dependent manner and exhibited more activity at the dose of 300 mg/kg when compared with diazepam treated animals. In PTZ method, the extract inhibited convulsions in mice potent than phenobarbitone sodium. In INH method, it delayed the latency of convulsions in mice in a dose-dependent manner but failed to protect the mice against mortality. Conclusion The chloroform extract exhibited significant and dose-dependent antiepileptic activity, which may be due to the presence of antioxidant principles like flavanoids.

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      Govindu, S., & Adikay, S. (2014). Evaluation of antiepileptic activity of chloroform extract of Acalypha fruticosa in mice. Pharmacognosy Research, 6(2), 108–112. https://doi.org/10.4103/0974‑8490.128970