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    Inhibitory effects by ayurvedic plants on prostate enlargement induced in rats

    Rahul K. Dumbre1★, Manisha B. Kamble2, Vijay R. Patil1★ Corresponding author

    1. 1Department of Pharmacognosy, TVES’s Loksevak Madhukarrao Chaudhari College of Pharmacy, Faizpur, Maharashtra
    2. 2Department of Pharmacognosy, Rajgad Dyanpeeth’s College of Pharmacy, Bhor, Pune, Maharashtra, India

    CORRESPONDENCE

    Rahul K. Dumbre

    *Address for correspondence: Mr. Rahul K. Dumbre, Flat no 408, Prathamesh, Jai Ganesh Vishwa, Gokulnagar, Katraj Kondhwa Road, Pune - 411 048, Maharashtra, India.

    rahuldumbre@hotmail.com

    Revised: 16-08-2013.

    Volume 6, Issue 2 · pp. 127–132 · PUBLISHED April-June 2014 · DOI: 10.4103/0974-8490.129031

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Background Ayurveda recommends several plants and plant preparation for conditions of urogenital disorders as per its principles. Objectives: Ayurvedic plants Tamala (Cinnamomum tamala); Daruhalad (Berberis aristata); Ativish (Aconitum heterophyllum) were studied for mechanisms of prostatic hyperplasia induced in rats. Materials and Methods Prostatic enlargement was induced in castrated rats by testosterone injection s.c. for 21 days and simultaneously plants were dosed orally daily. On day 22 rats were sacrificed and prostate was removed; weight and volume of prostate was measured; histopathology performed. Inflammation was induced by injecting carrageenan in rat hind paw and inhibition was studied by measuring rat paw oedema at different time points. Results Tamala showed significant effect where it reduced prostatic enlargement and improved hyperplastic changes, while Daruhalad and Ativisha did not show any significant effect. All of them showed mild to moderate anti-inflammatory activity. Conclusion Study concludes that Tamala may benefit in prostate disorder by virtue of inhibition of androgen mechanisms in prostate and modulating inflammatory mediators in prostate. Daruhalad and Ativisha did not show any effect in this model of prostate enlargement while the anti-inflammatory effect may propose one of the useful properties when included in various formulations.

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      Dumbre, R. K., Kamble, M. B., & Patil, V. R. (2014). Inhibitory effects by ayurvedic plants on prostate enlargement induced in rats. Pharmacognosy Research, 6(2), 127–132. https://doi.org/10.4103/0974-8490.129031