Exploiting the phenomenal anti-ulcerogenic potential of Talinum portulacifolium ethanolic extract whole plant on Albino Rats: The therapeutic potential of Chinese Herb-mǎ chǐ xiàn kē (Portulacaceae)
Rohit Gundamaraju1★, Kotla Maheedhar1, Kim Kah Hwi2★ Corresponding author
- 1Department of Pharmacolgy, Malla Reddy Institute of Pharmaceutical Sciences, Maisammaguda, Dhulapally (Post via Hakimpet), Secunderabad, Andhra Pradesh, India
- 2Department of Physiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
CORRESPONDENCE
Rohit Gundamaraju
*Address for correspondence: Mr. Rohit Gundamaraju, Research Scholar, 9-47, New Dilsukhnagar Colony, Hyderabad - 500 060, India.
Revised: 06-01-2014.
Volume 6, Issue 3 · pp. 227–233 · PUBLISHED July-September 2014 · DOI: 10.4103/0974-8490.132600
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ABSTRACT
Background Ulcerations have been effecting humans and causing major damage in the gastro intestinal tract. A need for development of a flawless anti-ulcer medication was always in the agenda. Thus, the need to conduct a study was provoked. Objectives The major objective of the present study is to screen the antiulcer activity of the ethanolic extract of Talinum portulacifolium (Forsk) plant. Materials and Methods The antiulcer activity of the ethanolic extract of T.Z portulacifolium was performed on albino rats. Gastric ulcers were induced by ethanol, pylorus ligated aspirin and histamine induced ulcer models. Omeprazole was used as a standard drug for comparison. Results Treatment with the T. portulacifolium plant extract significantly protected the ulceration induced by the three models. The gastric volume, pH of gastric juice, total acidity, free acidity and ulcer index were the parameters estimated and did show significant results. 800 mg/kg extracts of T. portulacifolium did show high significant results as that of standard drug. Percentage protection of 800 mg/kg was 79.9% and the standard drug-treated group did show 84%. So was with total acidity (38.1 + 1.45) and free acidity (16.5 + 0.76) Conclusion The ethanolic extract of T. portulacifolium plant was found to possess a significant antiulcer activity.
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Gundamaraju, R., Maheedhar, K., & Hwi, K. K. (2014). Exploiting the phenomenal anti-ulcerogenic potential of Talinum portulacifolium ethanolic extract whole plant on Albino Rats: The therapeutic potential of Chinese Herb-mǎ chǐ xiàn kē (Portulacaceae). Pharmacognosy Research, 6(3), 227–233. https://doi.org/10.4103/0974-8490.132600