Phcog.Net logo
Submit

BROWSE ALL JOURNALS

    SEE ALL 6 JOURNALS
    Pharmacognosy ResearchNOW IN
    Article

    Effect of ethanolic extract of Acacia auriculiformis leaves on learning and memory in rats

    Ajitha Sharma1★, Manjunath Shetty2, Amrita Parida3, Shalini Adiga3, Shobha Kamath4, Sowjanya4★ Corresponding author

    1. 1Department of Pharmacology, Pondicherry Institute of Medical Sciences, Puducherry
    2. 2Melaka Malaysian Medical College, Manipal
    3. 3Kasturba Medical College
    4. 4Department of Biochemistry, Kasturba Medical College, Manipal, Karnataka, India

    CORRESPONDENCE

    Ajitha Sharma

    *Address for correspondence: Dr. Ajitha Sharma, Department of Pharmacology; Pondicherry Institute of Medical Sciences, Puducherry, India.

    drajithasharma@gmail.com

    Revised: 26-03-2014.

    Volume 6, Issue 3 · pp. 246–250 · PUBLISHED July-September 2014 · DOI: 10.4103/0974-8490.132605

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Background The effects and benefits of Acacia auriculiformis on health are not well established. This study was planned to evaluate the effect of ethanolic extract of Acacia auriculiformis leaves on learning and memory in rats. Materials and Methods Learning and memory were evaluated using passive avoidance paradigm and rewarded alternation test (T-maze) after the oral administration of two doses (200mg/kg and 400mg/kg) of ethanolic extract of Acacia auriculiformis with rivastigmine as positive control. Forty eight rats were divided into 4 groups in each study model. Estimation of brain cholinesterase activity was done to substantiate the results of the above mentioned tests. Data was analyzed using one way Analysis of Variance (ANOVA) followed by Tukey’s post-hoc test using GraphPad InStat software, version 3.06. Results The extract produced a dose-dependent improvement in the memory score namely the step through latency in passive avoidance model (P < 0.001) and the percentage of correct responses in rewarded alternation test (P < 0.05). Dose-dependent inhibition of brain cholinesterase activity (P < 0.001) was also noted. Conclusion The acetylcholinesterase inhibiting property of Acacia auriculiformis contributes to its memory enhancing potential. Further large scale studies are required to elucidate its benefits on cognitive function. This may offer a promising new option for the treatment of dementia and other cognitive deficits.

    KEYWORDS

    Open in new tab

    REFERENCES

    As published

    Showing references and in-text citations exactly as published.

      Cite this article

      SELECT FORMAT

      Sharma, A., Shetty, M., Parida, A., Adiga, S., Kamath, S., & Sowjanya (2014). Effect of ethanolic extract of Acacia auriculiformis leaves on learning and memory in rats. Pharmacognosy Research, 6(3), 246–250. https://doi.org/10.4103/0974-8490.132605