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    Acute oral toxicity studies of Swietenia macrophylla seeds in Sprague Dawley rats

    Madhu Katyayani Balijepalli1, Velan Suppaiah2, An-me Chin2, Ayuba Sunday Buru2, Sreenivasa Rao Sagineedu2, Mallikarjuna Rao Pichika2★★ Corresponding author

    1. 1Department of Pharmacology, Faculty of Medicine, MAHSA University, Jalan University Campus, JalanElmu, Off Jalan University, 59100
    2. 2Department of Pharmaceutical Chemistry, School of Pharmacy, International Medical University, 126, JalanJalil Perkasa 19, Bukit Jalil, 57000, Kuala Lumpur, Malaysia

    CORRESPONDENCE

    Mallikarjuna Rao Pichika

    *Address for correspondence: prof. Mallikarjuna Rao Pichika, Department of Pharmaceutical Chemistry, School of Pharmacy, International Medical University, Bukit Jalil 57000, Kuala Lumpur, Malaysia.

    mallikarjunarao_pichika@imu.edu.my

    Revised: 08-07-2014.

    Volume 7, Issue 1 · pp. 38–44 · PUBLISHED January-March 2015 · DOI: 10.4103/0974-8490.147197

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Background Swietenia macrophylla King. (Meliaceae) seeds (SMS); commonly known as sky fruit and locally known in Malaysia as Tunjuk Langit; have been used in traditional Malay medicine for the treatment of diabetes and hypertension. The people eat only a tiny amount of raw seed, weighing not more than 5 mg. Aim To evaluate the safety of Swietenia macrophylla seeds (SMS) at a single-dose oral administration of 2 g/kg body weight (bw) in sprague dawley (SD) rats. Materials and Methods Eight-week old male and female SD rats were administered a single-oral dose of 2g/kg bw. The rats’ general behavior, and toxic signs were observed throughout the 14-day study period. The food and water intake by rats and their body weight were monitored during the study period. At the end of the study period, the relative weights of the organs (lung, liver, spleen, heart, kidney, testis, stomach); the hematological and biochemical parameters were measured; the architecture and histology of the organs (liver, kidney and lungs) were observed. Results Oral administration of SMS to rats did not affect, either food or water intake; relative organ weight of vital organs; the hematological and biochemical parameters; did not show significant changes in the architecture and histology of vital organs. Overall, there were neither signs of toxicity nor deaths recorded during the study period. Conclusion The rat dose of 2 g/kg bw is equivalent to the human dose of 325 mg/kg bw, which is well below the usual amount consumed by people, did not show any signs of toxicity in rats.

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      Balijepalli, M. K., Suppaiah, V., Chin, A., Buru, A. S., Sagineedu, S. R., & Pichika, M. R. (2015). Acute oral toxicity studies of Swietenia macrophylla seeds in Sprague Dawley rats. Pharmacognosy Research, 7(1), 38–44. https://doi.org/10.4103/0974-8490.147197