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    The optimization of essential oils supercritical CO2 extraction from Lavandula hybrida through static-dynamic steps procedure and semi-continuous technique using response surface method

    Hossein Kamali1, Noushin Aminimoghadamfarouj1, Ebrahim Golmakani2, Alireza Nematollahi1★★ Corresponding author

    1. 1Research Center of Natural Products Health, North Khorasan University of Medical Sciences, Bojnurd
    2. 2Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    CORRESPONDENCE

    Alireza Nematollahi

    *Address for correspondence: Dr. Alireza Nematollahi, Research Center of Natural Products Health, North Khorasan University of Medical Sciences, Bojnurd, Iran.

    alireza_nemat@yahoo.com

    Revised: 04-06-2014.

    Volume 7, Issue 1 · pp. 57–65 · PUBLISHED January-March 2015 · DOI: 10.4103/0974-8490.147209

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Aim The aim of this study was to examine and evaluate crucial variables in essential oils extraction process from Lavandula hybrida through static-dynamic and semi-continuous techniques using response surface method. Materials and Methods Essential oil components were extracted from Lavandula hybrida (Lavandin) flowers using supercritical carbon dioxide via static-dynamic steps (SDS) procedure, and semi-continuous (SC) technique. Results Using response surface method the optimum extraction yield (4.768%) was obtained via SDS at 108.7 bar, 48.5°C, 120 min (static: 8×15), 24 min (dynamic: 8×3 min) in contrast to the 4.620% extraction yield for the SC at 111.6 bar, 49.2°C, 14 min (static), 121.1 min (dynamic). Conclusion The results indicated that a substantial reduction (81.56%) solvent usage (kg CO2/g oil) is observed in the SDS method versus the conventional SC method.

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      Kamali, H., Aminimoghadamfarouj, N., Golmakani, E., & Nematollahi, A. (2015). The optimization of essential oils supercritical CO2 extraction from Lavandula hybrida through static-dynamic steps procedure and semi-continuous technique using response surface method. Pharmacognosy Research, 7(1), 57–65. https://doi.org/10.4103/0974-8490.147209