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    Inhibition of Group IIA Secretory Phospholipase A2 and its Inflammatory Reactions in Mice by Ethanolic Extract of Andrographis paniculata, a Well-known Medicinal Food

    V. Kishore1, N. S. Yarla2, F. Zameer3, M. N. Nagendra Prasad4, M. S. Santosh5, S. S. More6, D. G. Rao2, Bhadrapura Lakkappa Dhananjaya7★★ Corresponding author

    1. 1Department of Research, School of Chemical and Biotechnology, SASTRA University, Thanjavur, Tamil Nadu
    2. 2Department of Biochemistry/Bioinformatics, Institute of Science, GITAM University, Visakhapatnam, Andhra Pradesh
    3. 3Department of Studies in Biotechnology, Microbiology and Biochemistry, Mahajana Life Science Research Centre, SBRR Mahajana First Grade College, Affiliated to University of Mysore
    4. 4Department of Biotechnology, Sri Jayachamarajendra College of Engineering, JSS Institution Campus, Mysore
    5. 5Chemical Biology Unit, Centre for Emerging Technologies, Jain University, Ramanagara
    6. 6Department of Basic and Applied Sciences, Dayananda Sagar University, Bengaluru
    7. 7Toxinology/Toxicology and Drug Discovery Unit, Centre for Emerging Technologies, Jain University, Kanakapura, Karnataka, India

    CORRESPONDENCE

    Bhadrapura Lakkappa Dhananjaya

    Toxinology/Toxicology and Drug Discovery Unit, Centre for Emerging Technologies, Jain Global Campus, Jain University, Ramanagara - 562 112, Karnataka, India.

    chandu_greeshma@rediffmail.com

    Volume 8, Issue 3 · pp. 213–216 · PUBLISHED Jul-Sep 2016 · DOI: 10.4103/0974-8490.182916

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Andrographis paniculata Nees is an important medicinal plant found in the tropical regions of the world, which has been traditionally used in Indian and Chinese medicinal systems. It is also used as medicinal food. A. paniculata is found to exhibit anti-inflammatory activities; however, its inhibitory potential on inflammatory Group IIA phospholipases A2 (PLA2) and its associated inflammatory reactions are not clearly understood. The aim of the present study is to evaluate the inhibitory/neutralizing potential of ethanolic extract of A. paniculata on the isolated inflammatory PLA2 (VRV-PL-VIIIa) from Daboii rusellii pulchella (belonging to Group IIA inflammatory secretory PLA2 [sPLA2]) and its associated edema-induced activities in Swiss albino mice. A. paniculata extract dose dependently inhibited the Group IIA sPLA2 enzymatic activity with an IC50 value of 10.3 ± 0.5 mg/ml. Further, the extract dose dependently inhibited the edema formation, when co-injected with enzyme indicating that a strong correlation exists between lipolytic and pro-inflammatory activities of the enzyme. In conclusion, results of this study shows that the ethanolic extract of A. paniculata effectively inhibits Group IIA sPLA2 and its associated inflammatory activities, which substantiate its anti-inflammatory properties. The results of the present study warranted further studies to develop bioactive compound (s) in ethanolic extract of A. paniculata as potent therapeutic agent (s) for inflammatory diseases.

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      Kishore, V., Yarla, N. S., Zameer, F., Prasad, M. N. N., Santosh, M. S., More, S. S., Rao, D. G., & Dhananjaya, B. L. (2016). Inhibition of Group IIA Secretory Phospholipase A2 and its Inflammatory Reactions in Mice by Ethanolic Extract of Andrographis paniculata, a Well-known Medicinal Food. Pharmacognosy Research, 8(3), 213–216. https://doi.org/10.4103/0974-8490.182916