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    Croton grewioides Baill. (Euphorbiaceae) Shows Antidiarrheal Activity in Mice

    Anne Dayse Soares da Silva1, Karoline de Melo e Silva2, José Clementino Neto2, Vicente Carlos de Oliveira Costa3, Hilzeth de Luna F. Pessôa4, Josean Fechine Tavares1,5, Marcelo Sobral da Silva1,5, Fabiana de Andrade Cavalcante1,6★★ Corresponding author

    1. 1Postgraduate Program in Natural Products and Synthetic Bioactive, Federal University of Paraíba, João Pessoa 58051-900, PB, Brazil
    2. 2Institute of Biological Sciences and Health, Federal University of Alagoas, Maceió 57020-720, AL, Brazil
    3. 3Institute for Research on Drugs and Medicines, Federal University of Paraíba, João Pessoa 58051- 900, PB, Brazil
    4. 4Department of Molecular Biology, Federal University of Paraíba, João Pessoa 58051-900, PB, Brazil
    5. 5Department of Pharmaceutical Sciences, Federal University of Paraíba, João Pessoa 58051-900, PB, Brazil
    6. 6Department of Physiology and Pathology, Federal University of Paraíba, João Pessoa 58051-900, PB, Brazil

    CORRESPONDENCE

    Fabiana de Andrade Cavalcante

    Prof. Dr. Fabiana de Andrade Cavalcante, Postgraduate Program in Natural Products and Synthetic Bioactive, Federal University of Paraíba, João Pessoa 58051-900, PB, Brazil. Department of Physiology and Pathology, Federal University of Paraíba, João Pessoa 58051-900, PB, Brazil.

    fabianacavalcante@ltf.ufpb.br

    Volume 8, Issue 3 · pp. 202–205 · PUBLISHED Jul-Sep 2016 · DOI: 10.4103/0974-8490.181465

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Based on chemotaxonomy, we decided to investigate the possible antidiarrheal activity in mice of a crude ethanolic extract obtained from aerial parts of Croton grewioides (CG-EtOH). We tested for any possible toxicity in rat erythrocytes and acute toxicity in mice. Antidiarrheal activity was assessed by determining the effect of CG-EtOH on defecation frequency, liquid stool, intestinal motility and intestinal fluid accumulation. CG-EtOH showed no in vitro cytotoxicity and was not orally lethal. In contrast, the extract given intraperitoneally (at 2000 mg/kg) was lethal, but only in females. CG-EtOH produced a significant and equipotent antidiarrheal activity, both in defecation frequency (ED50=106.0 ± 8.1 mg/kg) and liquid stools (ED50=105.0 ± 9.2 mg/kg). However, CG-EtOH (125 mg/kg) decreased intestinal motility by only 22.7% ±4.4%. Moreover, extract markedly inhibited the castor oil-induced intestinal contents (ED50=34.6 ± 5.4 mg/kg). We thus conclude that CG-EtOH is not orally lethal and contains active principles with antidiarrheal activity, and this effect seems to involve mostly changes in intestinal secretion.

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      Silva, A. D. S. D., Silva, K. D. M. E., Neto, J. C., Costa, V. C. D. O., Pessôa, H. D. L. F., Tavares, J. F., Silva, M. S. D., & Cavalcante, F. D. A. (2016). Croton grewioides Baill. (Euphorbiaceae) Shows Antidiarrheal Activity in Mice. Pharmacognosy Research, 8(3), 202–205. https://doi.org/10.4103/0974-8490.181465