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    Communication

    Potential of Cannabidiol for the Treatment of Viral Hepatitis

    Henry I. C. Lowe1, Ngeh J Toyang2★, Wayne McLaughlin3★ Corresponding author

    1. 1Flavocure Biotech LLC, Columbia; Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, USA; Medicanja Jamaica LTD, Kingston; Bio-Tech R and D, LTD, Mona, JAMAICA.
    2. 2Flavocure Biotech LLC, Columbia; Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, USA; Medicanja Jamaica LTD, Kingston, JAMAICA.
    3. 3Department of Basic Medical Sciences, University of the West Indies, Mona, JAMAICA.

    CORRESPONDENCE

    Ngeh J Toyang

    Flavocure Biotech LLC, Columbia; Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, USA; Medicanja Jamaica LTD, Kingston, JAMAICA.

    ngeh.toyang@flavocure.com

    Volume 9, Issue 1 · pp. 116–118 · PUBLISHED · DOI: 10.4103/0974-8490.199780

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Viral hepatitis B (HBV) and hepatitis C (HCV) pose a major health problem globally and if untreated, both viruses lead to severe liver damage resulting in liver cirrhosis and cancer. While HBV has a vaccine, HCV has none at the moment. The risk of drug resistance, combined with the high cost of current therapies, makes it a necessity for cost-effective therapeutics to be discovered and developed. The recent surge in interest in Medical Cannabis has led to interest in evaluating and validating the therapeutic potentials of Cannabis and its metabolites against various diseases including viruses. Preliminary screening of cannabidiol (CBD) revealed that CBD is active against HCV but not against HBVin vitro. CBD inhibited HCV replication by 86.4% at a single concentration of 10 μM with EC50of 3.163 μM in a dose-response assay. These findings suggest that CBD could be further developed and used therapeutically against HCV.

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      Lowe, H. I. C., Toyang, N. J., & McLaughlin, W. (). Potential of Cannabidiol for the Treatment of Viral Hepatitis. Pharmacognosy Research, 9(1), 116–118. https://doi.org/10.4103/0974-8490.199780