Volume 9, Issue 1

· pp. 1–118 · 19 articles

Volume: 9
Issue: 1
Published
Pages: 1–118
Articles: 19
Sections: 2
ISSN: ISSN: Print - 0976-4836, Online - 0974-8490
Journal: Pharmacogn. Res.

Original Article SHORT COMMUNICATION

In this issue

Original Article

Article
Antihyperglycemic Activity of the Leaves from Annona cherimola Miller and Rutin on Alloxan-induced Diabetic Rats
Fernando Calzada, Jesús Iván Solares-Pascasio, RM Ordoñez-Razo, Claudia Velazquez, Elizabeth Barbosa, Normand García-Hernández, David Mendez-Luna, José Correa-Basurto
pp. 1–6 · DOI: 10.4103/0974-8490.199781 · Published
Background:Annona cherimola, known as “chirimoya” has been reported in Mexican traditional medicine for the treatment of diabetes. Objective: The aims of the present study were to validate and assess the traditional use …
Article
Synergisms in Alpha‑glucosidase Inhibition and Antioxidant Activity of Camellia sinensis L. Kuntze and Eugenia uniflora L. Ethanolic Extracts
Juliana Vinholes, Márcia Vizzotto
pp. 101–107 · DOI: 10.4103/0974-8490.197797 · Published
Background: Camellia sinensis, the most consumed and popular beverages worldwide, and Eugenia uniflora, a Brazilian native species, have been already confirmed to have beneficial effects in the treatment of diabetes mell…
Article
Modulating Effect of Hypnea musciformis (Red Seaweed) on Lipid Peroxidation, Antioxidants and Biotransforming Enzymes in 7,12‑Dimethylbenz (a) Anthracene Induced Mammary Carcinogenesis in Experimental Animals
Mohan Balamurugan, Kathiresan Sivakumar, Arokia Vijaya Anand Mariadoss, Kathiresan Suresh
pp. 108–115 · DOI: 10.4103/0974-8490.187085 · Published
Background:Breast cancer is the second most widespread diagnosed cancer and second leading cause of cancer death in women. Objective:The present work was carried out to evaluate the chemo preventive potential of Hypnea m…
Article
The Influence of Pluronic F68 and F127 Nanocarrier on Physicochemical Properties, In vitro Release, and Antiproliferative Activity of Thymoquinone Drug
Salwa Shaarani, Shahrul Sahul Hamid, Noor Haida Mohd Kaus
pp. 12–20 · DOI: 10.4103/0974-8490.199774 · Published
Background:This study reports on hydrophobic drug thymoquinone (TQ), an active compound found in the volatile oil ofNigella sativathat exhibits anticancer activities. Nanoformulation of this drug could potentially increa…
Article
Evaluation of Cholesterol‑lowering Activity of Standardized Extract of Mangifera indica in Albino Wistar Rats
GM Gururaja, Deepak Mundkinajeddu, A Senthil Kumar, Shekhar Michael Dethe, J Joshua Allan, Amit Agarwal
pp. 21–26 · DOI: 10.4103/0974-8490.199770 · Published
Introduction:Cholesterol lowering activity ofMangifera indica L. has been determined by earlier researchers and kernel, leaf and bark have shown significant activity. However, the specific cholesterol lowering activity o…
Article
Chronic Intake of Green Propolis Negatively Affecting the Rat Testis
Grasiela Dias de Campos Severi-Aguiar, Suellen Josine Pinto, Cristina Capucho, Camila Andrea Oliveira, Maria Aparecida Diamante, Renata Barbieri, Fabrícia Souza Predes, Heidi Dolder
pp. 27–33 · DOI: 10.4103/0974-8490.199777 · Published
Background:Human and animal evidence suggests that environmental toxicants may have an adverse impact on male reproductive health, reducing the population’s reproductive output. Owing to the renewed attraction for natura…
Article
Analysis of Soluble Proteins in Natural Cordyceps sinensis from Different Producing Areas by Sodium Dodecyl Sulfate- Polyacrylamide Gel Electrophoresis and Two-dimensional Electrophoresis
Chun-Hong Li, Hua-Li Zuo, Qian Zhang, Feng-Qin Wang, Huan-Jia Hu, Zheng-Ming Qian, Wen-Jia Li, Zhi-Ning Xia, Feng-Qing Yang
pp. 34–38 · DOI: 10.4103/0974-8490.199782 · Published
Background: As one of the bioactive components in Cordyceps sinensis (CS), proteins were rarely used as index components to study the correlation between the protein components and producing areas of natural CS. Objectiv…
Article
Cosmeceutical Effects of Galactomannan Fraction from Arenga pinnata Fruits In vitro
Yanti Y, Madriena M, Soegianto Ali
pp. 39–45 · DOI: 10.4103/0974-8490.199773 · Published
Background:Cosmeceuticals refer to natural cosmetics with medical‑like benefits due to their bioactive contents. Sugar palm fruit (Arenga pinnata) extract has been claimed for its anti‑aging effect in vitro. However, its…
Article
Cytotoxicity Studies of the Extracts, Fractions, and Isolated Compound of Pseudocedrela kotschyi on Cervical Cancer (HeLa), Breast Cancer (MCF‑7) and Skeletal Muscle Cancer (RD) Cells
Taiwo O Elufioye, Abolaji A Abdul, Jone O Moody
pp. 46–50 · DOI: 10.4103/0974-8490.199776 · Published
Background:This study determined the cytotoxic effects of root and stem bark extracts, fractions, and isolated compounds derived from Pseudocedrela kotschyi on HeLa, MCF-7, and RD cells. Materials and Methods:The cytotox…
Article
Insulin Plant (Costus pictus) Extract Restores Thyroid Hormone Levels in Experimental Hypothyroidism
S Ashwini, Zachariah Bobby, M. G. Sridhar, C. C. Cleetus
pp. 51–59 · DOI: 10.4103/0974-8490.199766 · Published
Background: The aim of the present study was to investigate the preventive effect ofCostus pictusleaf extract in experimental hypothyroidism.Materials and Methods: Forty male Wistar rats were randomly divided into four g…
Article
Pharmacognostic Specifications and Lawsone Content of Lawsonia inermis Leaves
Rawiwan Charoensup, Thidarat Duangyod, Chanida Palanuvej, Nijsiri Ruangrungsi
pp. 60–64 · DOI: 10.4103/0974-8490.199775 · Published
Background:Lawsonia inermisL. has been used as a traditional or folk medicine for the treatment of a wide range of skin infectious diseases. Objective: The objective of this study was to determine the pharmacognostic spe…
Article
New Cytotoxic Cembranoid from Indonesian Soft Coral Sarcophyton sp.
Hedi Indra Januar, Neviaty Putri Zamani, Dedi Soedharma, Ekowati Chasanah
pp. 65–68 · DOI: 10.4103/0974-8490.199779 · Published
Context:Sarcophyton is a soft coral species that contains various secondary metabolites with cytotoxic activity. The production of cytotoxic compounds in soft corals is suggested as their allelochemical to win space comp…
Article
Short‑term Effects of Date Palm Extract (Phoenix dactylifera) on Ischemia/Reperfusion Injury Induced by Testicular Torsion/ Detorsion in Rats
Alireza Raayat Jahromi, Rokhsana Rasooli, Younes Kamali, Nasrollah Ahmadi, Ehsan Sattari
pp. 69–73 · DOI: 10.4103/0974-8490.199769 · Published
Background: Antioxidants are potent scavengers of free radicals and have beneficial effects on human health. Objective:The aim of this study was to investigate the potential protective antioxidant activity of the edible …
Article
Methanol Extract of Adansonia digitata Leaf Protects Against Sodium Arsenite‑induced Toxicities in Male Wistar Rats
Ayodeji Mathias Adegoke, Michael Adedapo Gbadegesin, Oyeronke Adunni Odunola
pp. 7–11 · DOI: 10.4103/0974-8490.199768 · Published
Background:Human and animal population exposure to arsenic through the consumption of arsenic contaminated water is rampant in many parts of the world. Protective agents of medicinal plants origin could provide maximum p…
Article
Growth Inhibition and Morphological Alteration of Fusarium sporotrichioides by Mentha piperita Essential Oil
P Rachitha, K Krupashree, GV Jayashree, Natarajan Gopalan, Farhath Khanum
pp. 74–79 · DOI: 10.4103/0974-8490.199771 · Published
Objective: The aim of this study is to determine the phytochemical composition, antifungal activity of Mentha piperitaessential oil (MPE) against Fusarium sporotrichioides. Methods: The phytochemical composition was cond…
Article
Antidiabetic Effects of Aqueous and Dichloromethane/Methanol Stem Bark Extracts of Pterocarpus soyauxii Taub (Papilionaceae) on Streptozotocin‑induced Diabetic Rats
Marie Claire Tchamadeu, Paul Désiré Djomeni Dzeufiet, Nelly Blaes, Jean-Pierre Girolami, Pierre Kamtchouing, Théophile Dimo
pp. 80–86 · DOI: 10.4103/0974-8490.199767 · Published
Aim of the Study:The aim is to evaluate the hypoglycemic and antidiabetic effects of aqueous and CH2Cl2/CH3OH stem bark extracts of Pterocarpus soyauxiiTaub in normal and diabetic rats. Materials and Methods:Streptozotoc…
Article
The Hydroalcoholic Extract of Matricaria chamomilla Suppresses Migration and Invasion of Human Breast Cancer MDA‑MB‑468 and MCF‑7 Cell Lines
Mohsen Nikseresht, Ali Mohammad Kamali, Hamid Reza Rahimi, Hamdollah Delaviz, Mehdi Akbartabar Toori, Iraj Ragerdi Kashani, Reza Mahmoudi
pp. 87–95 · DOI: 10.4103/0974-8490.199778 · Published
Background:Matricaria chamomilla is an aromatic plant with antioxidant, anticancer, and anti‑inflammatory properties. However, the inhibitory role of M. chamomilla on migration and invasion of human breast cancer cells r…
Article
Antifungal Activity of Hydroalcoholic Extract of Chrysobalanus icaco Against Oral Clinical Isolates of Candida Species
João Paulo Bastos Silva, Ana Regina Maués Noronha Peres, Thiago Portal Paixão, Andressa Santa Brígida Silva, Ana Cristina Baetas, Wagner Luiz Ramos Barbosa, Marta Chagas Monteiro, Marcieni Ataíde Andrade
pp. 96–100 · DOI: 10.4103/0974-8490.199772 · Published
Background:Chrysobalanus icaco is a medicinal plant commonly used to treat fungal infections in Brazilian Amazonian region. Objective:This work aimed to evaluate the antifungal activity of the hydroalcoholic extract of C…

SHORT COMMUNICATION

Communication
Potential of Cannabidiol for the Treatment of Viral Hepatitis
Henry I. C. Lowe, Ngeh J Toyang, Wayne McLaughlin
pp. 116–118 · DOI: 10.4103/0974-8490.199780 · Published
Viral hepatitis B (HBV) and hepatitis C (HCV) pose a major health problem globally and if untreated, both viruses lead to severe liver damage resulting in liver cirrhosis and cancer. While HBV has a vaccine, HCV has none…