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    Article

    Short‑term Effects of Date Palm Extract (Phoenix dactylifera) on Ischemia/Reperfusion Injury Induced by Testicular Torsion/ Detorsion in Rats

    Alireza Raayat Jahromi1, Rokhsana Rasooli2, Younes Kamali2★, Nasrollah Ahmadi3, Ehsan Sattari2★ Corresponding author

    1. 1Department of Clinical Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, IRAN.
    2. 2Department of Basic Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, IRAN.
    3. 3Department of Pathobiology, School of Veterinary Medicine, Shiraz University, Shiraz, IRAN.

    CORRESPONDENCE

    Younes Kamali

    Department of Basic Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, IRAN.

    youn.kamali@gmail.com

    Volume 9, Issue 1 · pp. 69–73 · PUBLISHED · DOI: 10.4103/0974-8490.199769

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Background: Antioxidants are potent scavengers of free radicals and have beneficial effects on human health. Objective:The aim of this study was to investigate the potential protective antioxidant activity of the edible portion of date fruit extract in an experimental testicular torsion/detorsion (T/D) model in rats. Materials and Methods: To investigate the potential protective effects of date palm (DP), 30 male Spraque‑Dawley rats were divided into three groups: sham‑operated, T/D, and T/D + DP‑treated (500 mg/kg, PO) groups. Testicular ischemia was induced via keeping the left testis under 720° clockwise torsion for 2 h (h), afterward, detorsion was performed. All rats were sacrificed 4 h after detorsion. Serum malondialdehyde (MDA) concentration, total oxidative status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), and histopathological damage score were evaluated. Results:Serum MDA, TOS, and OSI levels rose significantly in the T/D group. These values were lower in the T/D + DP group. TAS values decreased significantly in T/D group and rose in T/D + DP group. Severe injury was seen in the twisted testes of T/D group. In contrast, ipsilateral‑twisted testicular tissue in the DP‑treated group showed moderate‑to‑mild changes. Contralateral testicular tissue in the T/D group had a mild‑to‑moderate tissue injury; meanwhile, treated group revealed normal‑to‑mild changes. Spermatogenesis was significantly improved in DP‑treated group when compared with the T/D group. Conclusion: The findings suggest a possible protective effect of DP against testicular oxidative damage induced by T/D; however, more detailed studies are warranted.

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      Jahromi, A. R., Rasooli, R., Kamali, Y., Ahmadi, N., & Sattari, E. (). Short‑term Effects of Date Palm Extract (Phoenix dactylifera) on Ischemia/Reperfusion Injury Induced by Testicular Torsion/ Detorsion in Rats. Pharmacognosy Research, 9(1), 69–73. https://doi.org/10.4103/0974-8490.199769