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    Pharmacognosy ResearchNOW IN
    Article

    Effect of Tamarindus indica L. and Manihot esculenta Extracts on Antibiotic‑resistant Bacteria

    Zenon Machado Lima1, Lenilson Santos da Trindade1, Genelane Cruz Santana2, Francine Ferreira Padilha1, Marcelo da Costa Mendonca1, Luiz Pereira da Costa3, Jorge A Lopez1, Maria Lucila Hernández Macedo1★★ Corresponding author

    1. 1Program in Industrial Biotechnology- Tiradentes University/ Institute of Technology and Research, Aracaju-SE, BRAZIL.
    2. 2Material Science and Engineering- Federal University of Sergipe, Aracaju-SE, BRAZIL.
    3. 3Program in Industrial Biotechnology- Tiradentes University/ Institute of Technology and Research; Biomaterials and Nanotechnology Laboratory- Technological Institute and Research of the Sergipe State, Aracaju-SE, BRAZIL.

    CORRESPONDENCE

    Maria Lucila Hernández Macedo

    Program in Industrial Biotechnology- Tiradentes University/ Institute of Technology and Research, Aracaju-SE, BRAZIL.

    lucyherma@gmail.com

    Volume 9, Issue 2 · pp. 195–199 · PUBLISHED 1 April 2021 · DOI: 10.4103/0974-8490.204648

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Background:The chemical composition of plants used in traditional medicine exhibits biologically active compounds, such as tannins, flavonoids, and alkaloids and becomes a promising approach to treat microbial infections, mainly with drug-resistant bacteria.Objective: The aim of the present study was to evaluate the hydroethanolic leaf extracts ofTamarindus indica (tamarind) and Manihot esculenta(cassava) as antimicrobial potential againstPseudomonas aeruginosa clinical isolated and Methicillin-resistantStaphylococcus aureus.Materials and Methods: Hydroethanolic leaf extracts were prepared and characterized by high-performance liquid chromatography/diode array detection, Fourier transform infrared, 1,1-diphenyl-2-picrylhydrazyl, and ultraviolet-visible methods. The antimicrobial activity against four strains of clinical relevance was evaluated by the microdilution method at minimum inhibitory concentrations. Results: Phenolic compounds such as flavonoids were detected in the plant extracts.T. indica extract at 500 μg/mL showed antimicrobial activity against S. aureus and P. aeruginosa; however, M. esculentashowed only activity against P. aeruginosa in this concentration. Conclusions:Our results suggested that polyphenols and flavonoids present in T. indica leaf extracts are a potential source of antimicrobial compound. TheT. indicaextract showed antibacterial activity against S. aureus and P. aeruginosawhile M. esculenta had effect only on P. aeruginosameropenem resistant.

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      Lima, Z. M., Trindade, L. S. D., Santana, G. C., Padilha, F. F., Mendonca, M. D. C., Costa, L. P. D., Lopez, J. A., & Macedo, M. L. H. (2021). Effect of Tamarindus indica L. and Manihot esculenta Extracts on Antibiotic‑resistant Bacteria. Pharmacognosy Research, 9(2), 195–199. https://doi.org/10.4103/0974-8490.204648