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    Free Radicals and AntioxidantsNOW IN
    Review

    Therapeutic Potential of Vitex negundo: A Comprehensive Review of Its Medicinal Properties

    Jothi Dheivasikamani Abidharini1★, Arthi Gunasekaran1, Jeyabal Philomenathan Antony Prabhu1, Asirvatham Alwin Robert2, Arumugan Vijaya Anand1, Palanisami Sampathkumar3★ Corresponding author

    1. 1Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore, Tamil Nadu, INDIA.
    2. 2Department of Endocrinology and Diabetes, Prince Sultan Military Medical City, Ministry of Defense, Riyadh, SAUDI ARABIA.
    3. 3Department of Chemistry and Biosciences, SASTRA Deemed to be University, Srinivasa Ramanujan Centre, Kumbakonam, Tamil Nadu, INDIA.

    CORRESPONDENCE

    Jothi Dheivasikamani Abidharini

    Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore, Tamil Nadu, INDIA.

    omnamashivaya879@gmail.com

    Received: 08-01-2026; Revised: 27-02-2026; Accepted: 18-04-2026.

    Volume 15, Issue 2 · pp. 42–48 · PUBLISHED 2025 · DOI: 10.5530/fra.2025.2.6

    View on Free Rad. Antiox. original site ↗

    ABSTRACT

    Vitex negundo L., commonly known as Nochi in Tamil, is a widely distributed medicinal plant valued in traditional medicine for its diverse therapeutic properties. It contains a rich array of secondary metabolites, including flavonoids, alkaloids, tannins, and phenolic compounds, which contribute to its broad pharmacological potential. This review aims to provide a comprehensive overview of the general medicinal significance of based on existing scientific and ethnobotanical evidence. To summarize its phytochemical composition, highlight its general pharmacological activities, and discuss its role in traditional medicine, along with current research trends and conservation concerns. The available literature on the plant’s bioactive constituents, extraction methods, and reported biological activities highlights its potential as a source of natural products. V. negundo represents a valuable medicinal resource with promising applications in natural product research and drug development. Further studies on its bioactive compounds, standardization, and sustainable extraction are necessary to explore and harness its therapeutic potential fully. This review highlights the multifaceted role of V. negundo in disease prevention and treatment, emphasizing the need for further pharmacological and clinical investigations to establish its efficacy and safety for modern therapeutic use

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      Abidharini, J. D., Gunasekaran, A., Prabhu, J. P. A., Robert, A. A., Anand, A. V., & Sampathkumar, P. (2025). Therapeutic Potential of Vitex negundo: A Comprehensive Review of Its Medicinal Properties. Free Radicals and Antioxidants, 15(2), 42–48. https://doi.org/10.5530/fra.2025.2.6