Phcog.Net logo
Submit

BROWSE ALL JOURNALS

    SEE ALL 6 JOURNALS
    Free Radicals and AntioxidantsNOW IN
    Article

    Antioxidant Effect of Aqueous Extract of Triticum aestivum Grass on Insulin Resistance models in Wistar Albino Rats

    Jayanti Prava Behera1, Yerramalli Roja Ramani1★, Itishree Prusty1, Sahu Swapna Rohit1★ Corresponding author

    1. 1Department of Pharmacology, MKCG MC Berhampur, INDIA.

    CORRESPONDENCE

    Yerramalli Roja Ramani

    Department of Pharmacology, MKCG MC Berhampur, INDIA.

    yrramani@gmail.com

    Volume 5, Issue 2 · pp. 43–51 · PUBLISHED · DOI: 10.5530/fra.2015.2.1

    View on Free Rad. Antiox. original site ↗

    ABSTRACT

    Context:Prolonged use of hypoglycaemic drugs is problematic due to their toxic side effects and diminution of response. Oral antihyperglycaemic agents from plant sources are therefore being explored for use in traditional medicine. Aims: To study antihyperglycaemic, hypolipidemic and antioxidant effect of aqueous extract of Triticum aestivum grass (TAGE) in two different models of T2DM in wistar albino rats such as High Fat Diet with Low dose STZ and High Fructose Diet models.Settings and Design: Two models of insulin resistance were used (single i.p injection of STZ (45 mg/kg) with high fat diet and fructose 10% w/v, p.o, ad libitum). Methods and Material: STZ with high fat diet and fructose 10% w/v, p.o, in rats was administered for a period of 21 days. Three doses of TAGE (40, 60 and 80 mg/kg, p.o) were used. Pioglitazone (PG) 20 mg/kg was used as the reference standard. At the end of the experimental period, serum biochemical parameters like fasting blood sugar, plasma insulin, lipid profile and MDA and SOD activity were studied in both the models. Statistical analysis used:one way ANOVA followed by Turkey’s multiple comparison test. p<0.05 was considered as significant. Results: In both the models, TAGE significantly lowered plasma glucose, lipid, MDA level and increased SOD activity. It also improved insulin resistance which is comparable to that of normal and standard group. Conclusion: TAGE may be a potent drug, for treatment and prevention of complications of T2DM used alone or in combination with other oral hypoglycaemic agents.

    KEYWORDS

    Open in new tab

    REFERENCES

    As published

    Showing references and in-text citations exactly as published.

      Cite this article

      SELECT FORMAT

      Behera, J. P., Ramani, Y. R., Prusty, I., & Rohit, S. S. (). Antioxidant Effect of Aqueous Extract of Triticum aestivum Grass on Insulin Resistance models in Wistar Albino Rats. Free Radicals and Antioxidants, 5(2), 43–51. https://doi.org/10.5530/fra.2015.2.1