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    Free Radicals and AntioxidantsNOW IN
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    Correlation of Anticancer Effects of 12 Iranian Herbs on Human breast Adenocarcinoma cells with antioxidant Properties

    Reyhane Hoshyar1★, Seyedeh Elham Mostafavinia2, Asghar Zarban1, Mohammad Hassanpour3, Mozhde Partovfari4, Amir Taheri5, Mohsen Pouyan6★ Corresponding author

    1. 1Department of Biochemistry, Faculty of Medicine, Metabolism & Antioxidants Research Center, Birjand University of Medical Sciences, Birjand, IRAN.
    2. 2Department of Biochemistry, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, IRAN.
    3. 3Department of Pharmacology, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, IRAN.
    4. 4Department of Biology, College of Sciences, Shiraz University, Shiraz, IRAN.
    5. 5Metabolism & Antioxidants Research Center, Birjand University of Medical Sciences, Birjand, IRAN.
    6. 6Department of plant protection, Jihad-Agriculture Education Centre of South Khorasan, IRAN.

    CORRESPONDENCE

    Reyhane Hoshyar

    Department of Biochemistry, Faculty of Medicine, Metabolism & Antioxidants Research Center, Birjand University of Medical Sciences, Birjand, IRAN.

    reyhaneh.houshyar@gmail.com

    Volume 5, Issue 2 · pp. 65–73 · PUBLISHED · DOI: 10.5530/fra.2015.2.4

    View on Free Rad. Antiox. original site ↗

    ABSTRACT

    Introduction: Many of Medicinal plants have been investigated for possible anticancer properties. The correlation cytotoxic effect of herbs with antioxidant activity is unclear, yet. The aim of the present study was to examine the antioxidant contents and anticancer effects of 12 Iranian medicinal plants on proliferation of breast cancer, MCF-7, and epithelial normal, MCf-10A, cells. Methods:Free radical scavenging and total antioxidant capacities of herbal waters assessed by DPPH and FRAP methods, respectively. Their total phenolic contents and cell viability determined by Folin–Ciocalteu and MTT assays, respectively. Results: Among the herbs, group A which contained relatively highest total phenolics content, antioxidant and free radical scavenging activities inhibited significantly greater growth of breast cancer cells in a dose- and time-dependent manner as compared to other groups. These medicinal plants were not cytotoxic components against normal cells. Conclusion:Therefore our results indicated that anti proliferative effects of 12 selected Iranian herbs showed a direct correlation with antioxidant properties. The herbs as natural antioxidants with fewer side effects could potentially improve the outcome of human breast cancer therapy. These findings endorse further investigations on these plants to determine their active metabolites and mode of action.

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      Hoshyar, R., Mostafavinia, S. E., Zarban, A., Hassanpour, M., Partovfari, M., Taheri, A., & Pouyan, M. (). Correlation of Anticancer Effects of 12 Iranian Herbs on Human breast Adenocarcinoma cells with antioxidant Properties. Free Radicals and Antioxidants, 5(2), 65–73. https://doi.org/10.5530/fra.2015.2.4