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    Article

    Effect of Simvastatin on Neuroinflammation in Microglial Cells Via Mitogen‑activated Protein Kinase and Nuclear Factor κB Pathways

    HongYing Ma2, DingAn Li3, Thamaraiselvan Rengarajan4, Kalaivani Manokaran5★★ Corresponding author

    1. 1Department of Neurology, Tangshan GongRen Hospital, Tangshan, Hebei Province.
    2. 2Hanzhong Central Hospital, 22 KangFu Road, Hanzhong, Shaanxi Province, PR China.
    3. 3Scigen Research and Innovation, Periyar Technology Business Incubator, Thanjavur, Tamil Nadu.
    4. 4Department of Medical Laboratory Technology, School of Allied Health Sciences, Manipal, Manipal Academy of Higher Education, Karnataka, India.

    CORRESPONDENCE

    Kalaivani Manokaran

    kalaivani.m@manipal.edu

    Received: 12-09-2017; Revised: 19-10-2017.

    Volume 14, Issue 55s · pp. S237–S244 · PUBLISHED 1 March 2018 · DOI: 10.4103/pm.pm_418_17

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Activated microglial cells are found in different sorts of the neurodegenerative process including Parkinson and Alzheimer. Suppressing the activated microglial cells developed as a novel procedure for the treatment of neuroinflammation‑based neurodegeneration. Materials and Methods: We have investigated the effects of simvastatin on memory impairment and inflammatory cytokines expression induced by transient cerebral ischemia in cultured microglial cells. Results: The lipopolysaccharide (LPS)‑activated microglial cells treated with simvastatin 3 μmol has decreased the inflammation which was indicated by the reduced levels of the nitric oxide (NO), tumor necrosis factor‑α, interleukin‑1 β, cyclooxygenase‑2, and inducible NO synthase. Simvastatin also delayed the activation of atomic component nuclear factor‑κB, p38 mitogen‑activated protein kinase, and the reactive oxygen species in LPS‑activated microglial cells. Moreover, simvastatin has provoked the outflow of heme oxygenase‑1 in BV‑2 microglial cells. Conclusions: The present study showed that the simvastatin antagonizes neuroinflammation and can be a potential restorative operator for treating neuroinflammatory ailments.

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      Ma, H., Li, D., Rengarajan, T., & Manokaran, K. (2018). Effect of Simvastatin on Neuroinflammation in Microglial Cells Via Mitogen‑activated Protein Kinase and Nuclear Factor κB Pathways. Pharmacognosy Magazine, 14(55s), S237–S244. https://doi.org/10.4103/pm.pm_418_17